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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
36.06
Human Site:
S275
Identified Species:
56.67
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Rat
Rattus norvegicus
Q9JIM0
706
80103
S275
S
S
V
V
T
A
L
S
P
G
E
T
V
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Chicken
Gallus gallus
Q9IAM7
700
80005
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Frog
Xenopus laevis
Q9W6K1
711
81112
S276
S
S
V
A
T
S
L
S
P
G
E
A
E
K
K
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
E249
V
V
W
G
H
E
H
E
C
K
I
A
P
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
F250
P
E
D
L
L
P
S
F
L
H
L
V
I
W
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
T336
S
T
V
A
T
S
L
T
P
E
E
A
L
Q
K
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
Y148
S
V
S
G
L
V
N
Y
F
G
K
S
T
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
I280
S
S
V
A
T
S
L
I
D
G
E
S
K
P
K
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
C271
S
S
V
A
T
S
L
C
E
A
E
A
Q
P
K
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
V270
S
S
V
A
T
S
L
V
P
G
E
A
V
P
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
100
86.6
N.A.
100
100
86.6
6.6
N.A.
0
N.A.
60
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
93.3
N.A.
100
100
86.6
13.3
N.A.
13.3
N.A.
86.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
60
60
80
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
60
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
34
0
7
0
0
0
7
0
74
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
7
0
7
7
7
80
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
14
0
0
0
0
0
74
0
0
0
0
7
% G
% His:
0
0
0
0
7
0
7
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
7
0
7
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
7
7
0
7
54
80
% K
% Leu:
0
0
0
7
14
0
80
0
7
0
7
0
7
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
7
0
0
67
0
0
0
7
20
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
87
74
7
0
0
74
7
54
0
0
0
14
0
7
0
% S
% Thr:
0
7
0
0
80
0
0
7
0
0
0
7
7
0
0
% T
% Val:
7
14
80
47
0
7
0
7
0
0
0
7
54
7
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _