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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
19.09
Human Site:
S422
Identified Species:
30
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S422
G
K
L
I
T
K
P
S
E
G
T
T
L
R
V
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S422
G
K
L
I
T
K
P
S
E
G
T
T
L
R
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S422
G
K
L
I
T
K
P
S
E
G
T
T
L
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S423
M
L
I
T
K
P
A
S
E
G
A
T
L
R
V
Rat
Rattus norvegicus
Q9JIM0
706
80103
S423
K
L
I
I
K
P
A
S
E
G
T
T
L
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S423
K
F
I
R
K
P
A
S
E
G
M
T
L
R
V
Chicken
Gallus gallus
Q9IAM7
700
80005
S423
K
L
L
S
R
P
A
S
E
E
V
T
L
R
V
Frog
Xenopus laevis
Q9W6K1
711
81112
L425
K
I
D
S
K
P
L
L
E
G
T
T
L
R
V
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
N355
A
E
R
E
R
L
G
N
P
Q
I
P
E
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
M356
A
Q
E
R
V
E
A
M
I
E
R
A
V
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
A447
L
N
I
T
P
A
N
A
K
R
I
G
L
R
Y
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
Q255
D
P
V
W
N
A
T
Q
N
F
F
I
S
Q
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
D411
G
R
S
E
A
N
I
D
D
S
E
R
L
R
P
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
G422
V
T
R
S
K
K
S
G
I
N
G
T
S
I
S
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
E431
E
D
I
A
E
I
L
E
S
A
D
T
I
K
V
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
46.6
60
N.A.
46.6
46.6
46.6
0
N.A.
0
N.A.
13.3
0
P-Site Similarity:
100
100
N.A.
100
N.A.
53.3
66.6
N.A.
53.3
46.6
46.6
20
N.A.
20
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
13.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
7
7
14
34
7
0
7
7
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
0
0
0
0
7
7
0
7
0
0
0
0
% D
% Glu:
7
7
7
14
7
7
0
7
54
14
7
0
7
0
0
% E
% Phe:
0
7
0
0
0
0
0
0
0
7
7
0
0
0
0
% F
% Gly:
27
0
0
0
0
0
7
7
0
47
7
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
34
27
0
7
7
0
14
0
14
7
7
7
0
% I
% Lys:
27
20
0
0
34
27
0
0
7
0
0
0
0
14
0
% K
% Leu:
7
20
27
0
0
7
14
7
0
0
0
0
67
0
0
% L
% Met:
7
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% M
% Asn:
0
7
0
0
7
7
7
7
7
7
0
0
0
0
0
% N
% Pro:
0
7
0
0
7
34
20
0
7
0
0
7
0
0
20
% P
% Gln:
0
7
0
0
0
0
0
7
0
7
0
0
0
7
7
% Q
% Arg:
0
7
14
14
14
0
0
0
0
7
7
7
0
67
0
% R
% Ser:
0
0
7
20
0
0
7
47
7
7
0
0
14
0
7
% S
% Thr:
0
7
0
14
20
0
7
0
0
0
34
67
0
0
0
% T
% Val:
7
0
7
0
7
0
0
0
0
0
7
0
7
0
60
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _