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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
15.45
Human Site:
S531
Identified Species:
24.29
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S531
T
R
A
R
A
L
R
S
Q
S
E
E
S
A
S
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
F531
T
R
A
R
A
L
R
F
Q
S
E
E
S
A
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
F531
T
R
A
R
A
L
R
F
Q
S
E
D
S
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S532
S
R
A
R
A
L
R
S
Q
S
E
T
S
T
S
Rat
Rattus norvegicus
Q9JIM0
706
80103
S532
S
R
A
R
A
L
R
S
Q
S
E
N
A
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S532
N
R
A
R
A
H
R
S
Q
F
E
D
S
A
S
Chicken
Gallus gallus
Q9IAM7
700
80005
E522
E
E
D
E
E
V
R
E
A
M
T
R
A
R
A
Frog
Xenopus laevis
Q9W6K1
711
81112
T531
E
A
I
Q
R
A
R
T
H
R
S
Q
A
P
D
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
T442
L
V
K
E
Y
F
Q
T
A
E
K
N
V
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
E444
D
N
A
T
R
V
E
E
L
V
D
R
Y
F
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
E538
E
Q
Y
S
A
I
E
E
G
G
L
A
T
S
A
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
E342
E
A
L
I
Q
R
A
E
D
E
H
T
G
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
S506
E
E
R
L
K
D
R
S
T
R
P
T
G
S
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
I517
A
E
E
M
K
A
L
I
K
Q
V
K
R
A
N
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
D554
N
Q
P
Q
A
L
E
D
I
P
A
E
V
E
P
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
93.3
N.A.
86.6
N.A.
80
80
N.A.
73.3
6.6
6.6
0
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
93.3
N.A.
93.3
N.A.
86.6
93.3
N.A.
80
26.6
33.3
20
N.A.
20
N.A.
40
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
47
0
54
14
7
0
14
0
7
7
20
40
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
7
0
7
7
0
7
14
0
0
7
% D
% Glu:
34
20
7
14
7
0
20
27
0
14
40
20
0
7
7
% E
% Phe:
0
0
0
0
0
7
0
14
0
7
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
7
0
0
14
0
0
% G
% His:
0
0
0
0
0
7
0
0
7
0
7
0
0
0
0
% H
% Ile:
0
0
7
7
0
7
0
7
7
0
0
0
0
0
0
% I
% Lys:
0
0
7
0
14
0
0
0
7
0
7
7
0
0
0
% K
% Leu:
7
0
7
7
0
40
7
0
7
0
7
0
0
0
7
% L
% Met:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
14
7
0
0
0
0
0
0
0
0
0
14
0
7
7
% N
% Pro:
0
0
7
0
0
0
0
0
0
7
7
0
0
7
7
% P
% Gln:
0
14
0
14
7
0
7
0
40
7
0
7
0
7
0
% Q
% Arg:
0
40
7
40
14
7
60
0
0
14
0
14
7
7
7
% R
% Ser:
14
0
0
7
0
0
0
34
0
34
7
0
34
14
47
% S
% Thr:
20
0
0
7
0
0
0
14
7
0
7
20
7
7
0
% T
% Val:
0
7
0
0
0
14
0
0
0
7
7
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
7
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _