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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
22.42
Human Site:
S538
Identified Species:
35.24
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S538
S
Q
S
E
E
S
A
S
A
F
S
A
D
D
L
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S538
F
Q
S
E
E
S
A
S
A
F
S
A
D
D
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S538
F
Q
S
E
D
S
A
S
A
F
S
A
E
D
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S539
S
Q
S
E
T
S
T
S
A
F
S
A
E
D
L
Rat
Rattus norvegicus
Q9JIM0
706
80103
S539
S
Q
S
E
N
A
A
S
A
F
S
A
D
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S539
S
Q
F
E
D
S
A
S
V
F
S
A
D
D
L
Chicken
Gallus gallus
Q9IAM7
700
80005
A529
E
A
M
T
R
A
R
A
H
R
S
E
G
V
V
Frog
Xenopus laevis
Q9W6K1
711
81112
D538
T
H
R
S
Q
A
P
D
V
E
M
S
D
E
D
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
L449
T
A
E
K
N
V
Q
L
S
L
L
T
E
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
E451
E
L
V
D
R
Y
F
E
E
A
K
S
N
K
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
A545
E
G
G
L
A
T
S
A
N
R
N
F
D
S
C
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
R349
E
D
E
H
T
G
N
R
K
Q
P
T
L
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
S513
S
T
R
P
T
G
S
S
Q
F
L
S
T
G
L
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
N524
I
K
Q
V
K
R
A
N
S
V
R
P
T
P
P
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
P561
D
I
P
A
E
V
E
P
K
G
N
D
R
P
T
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
93.3
N.A.
80
N.A.
80
86.6
N.A.
80
6.6
6.6
0
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
93.3
N.A.
93.3
N.A.
86.6
93.3
N.A.
86.6
26.6
40
26.6
N.A.
20
N.A.
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
0
7
7
20
40
14
34
7
0
40
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
7
0
7
14
0
0
7
0
0
0
7
40
40
7
% D
% Glu:
27
0
14
40
20
0
7
7
7
7
0
7
20
7
0
% E
% Phe:
14
0
7
0
0
0
7
0
0
47
0
7
0
0
0
% F
% Gly:
0
7
7
0
0
14
0
0
0
7
0
0
7
7
7
% G
% His:
0
7
0
7
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
7
7
0
0
0
14
0
7
0
0
7
0
% K
% Leu:
0
7
0
7
0
0
0
7
0
7
14
0
7
0
54
% L
% Met:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
14
0
7
7
7
0
14
0
7
0
0
% N
% Pro:
0
0
7
7
0
0
7
7
0
0
7
7
0
20
14
% P
% Gln:
0
40
7
0
7
0
7
0
7
7
0
0
0
7
0
% Q
% Arg:
0
0
14
0
14
7
7
7
0
14
7
0
7
0
0
% R
% Ser:
34
0
34
7
0
34
14
47
14
0
47
20
0
7
0
% S
% Thr:
14
7
0
7
20
7
7
0
0
0
0
14
14
0
7
% T
% Val:
0
0
7
7
0
14
0
0
14
7
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _