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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
7.88
Human Site:
S586
Identified Species:
12.38
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S586
G
R
G
Q
N
S
A
S
R
G
G
S
Q
R
G
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S586
G
R
G
Q
N
S
A
S
R
G
G
S
Q
R
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
L586
G
R
G
Q
N
S
A
L
R
G
G
S
Q
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
A585
G
A
R
G
Q
S
S
A
P
R
G
G
S
Q
R
Rat
Rattus norvegicus
Q9JIM0
706
80103
A585
G
G
R
G
Q
S
T
A
P
R
G
G
S
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
Q585
R
A
R
G
A
R
G
Q
S
S
A
A
R
G
G
Chicken
Gallus gallus
Q9IAM7
700
80005
G579
G
R
A
R
G
A
R
G
Q
N
S
A
A
R
G
Frog
Xenopus laevis
Q9W6K1
711
81112
T583
R
G
G
R
G
Q
S
T
T
T
R
G
T
S
R
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
E497
E
R
R
V
D
A
T
E
E
K
I
D
E
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
D496
F
Y
K
E
K
A
V
D
H
L
M
E
A
M
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
K593
T
K
D
L
Y
D
M
K
K
A
D
S
E
R
F
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
K394
K
D
L
V
R
F
T
K
R
R
I
Q
L
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
A584
G
R
G
K
A
S
S
A
M
K
Q
T
T
L
D
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
E571
T
Q
S
H
V
D
N
E
S
R
I
T
H
I
S
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
T606
K
R
G
A
A
A
K
T
T
A
A
A
K
K
A
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
93.3
N.A.
20
20
N.A.
6.6
26.6
6.6
6.6
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
40
33.3
N.A.
20
53.3
26.6
26.6
N.A.
13.3
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
26.6
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
13.3
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
7
7
20
27
20
20
0
14
14
20
14
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
7
14
0
7
0
0
7
7
0
0
7
% D
% Glu:
7
0
0
7
0
0
0
14
7
0
0
7
14
7
0
% E
% Phe:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% F
% Gly:
47
14
40
20
14
0
7
7
0
20
34
20
0
7
34
% G
% His:
0
0
0
7
0
0
0
0
7
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
20
0
0
7
7
% I
% Lys:
14
7
7
7
7
0
7
14
7
14
0
0
7
14
7
% K
% Leu:
0
0
7
7
0
0
0
7
0
7
0
0
7
7
0
% L
% Met:
0
0
0
0
0
0
7
0
7
0
7
0
0
7
0
% M
% Asn:
0
0
0
0
20
0
7
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
7
% P
% Gln:
0
7
0
20
14
7
0
7
7
0
7
7
20
14
0
% Q
% Arg:
14
47
27
14
7
7
7
0
27
27
7
0
7
34
20
% R
% Ser:
0
0
7
0
0
40
20
14
14
7
7
27
14
7
7
% S
% Thr:
14
0
0
0
0
0
20
14
14
7
0
14
14
0
0
% T
% Val:
0
0
0
14
7
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _