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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
20
Human Site:
S602
Identified Species:
31.43
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S602
A
D
T
G
L
E
T
S
T
R
S
R
N
S
K
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S602
A
H
T
G
L
E
T
S
T
R
S
R
N
S
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S602
V
G
T
G
L
E
T
S
T
R
G
R
S
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
T601
R
D
T
G
L
E
I
T
T
R
G
R
S
S
K
Rat
Rattus norvegicus
Q9JIM0
706
80103
S601
R
D
T
G
L
G
I
S
T
R
G
R
S
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
C601
R
R
G
R
G
S
S
C
Q
E
S
P
N
R
S
Chicken
Gallus gallus
Q9IAM7
700
80005
T595
S
R
R
G
R
G
N
T
S
Q
G
S
S
T
S
Frog
Xenopus laevis
Q9W6K1
711
81112
D599
G
R
G
S
A
S
A
D
Q
P
S
S
G
R
A
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
N513
Q
F
R
D
S
K
R
N
T
A
E
E
D
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
L512
D
E
N
I
D
E
E
L
E
R
F
R
A
L
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
M609
N
P
V
A
D
V
E
M
E
E
D
E
D
D
P
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
S410
G
E
F
I
L
F
L
S
I
N
F
L
K
P
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
Q600
S
L
G
F
R
Q
S
Q
R
S
A
S
A
A
A
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
S587
A
E
S
S
K
P
T
S
K
P
K
R
V
R
T
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
A622
P
G
K
K
A
A
P
A
K
K
A
A
P
A
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
93.3
N.A.
73.3
N.A.
66.6
66.6
N.A.
13.3
6.6
6.6
6.6
N.A.
20
N.A.
0
13.3
P-Site Similarity:
100
93.3
N.A.
80
N.A.
80
73.3
N.A.
20
46.6
6.6
33.3
N.A.
26.6
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
40
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
7
14
7
7
7
0
7
14
7
14
14
14
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
7
20
0
7
14
0
0
7
0
0
7
0
14
7
0
% D
% Glu:
0
20
0
0
0
34
14
0
14
14
7
14
0
7
14
% E
% Phe:
0
7
7
7
0
7
0
0
0
0
14
0
0
0
0
% F
% Gly:
14
14
20
40
7
14
0
0
0
0
27
0
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
14
0
0
14
0
7
0
0
0
0
0
0
% I
% Lys:
0
0
7
7
7
7
0
0
14
7
7
0
7
0
40
% K
% Leu:
0
7
0
0
40
0
7
7
0
0
0
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
7
0
7
0
0
0
7
7
0
7
0
0
20
0
0
% N
% Pro:
7
7
0
0
0
7
7
0
0
14
0
7
7
7
7
% P
% Gln:
7
0
0
0
0
7
0
7
14
7
0
0
0
0
0
% Q
% Arg:
20
20
14
7
14
0
7
0
7
40
0
47
0
20
0
% R
% Ser:
14
0
7
14
7
14
14
40
7
7
27
20
27
34
14
% S
% Thr:
0
0
34
0
0
0
27
14
40
0
0
0
0
7
7
% T
% Val:
7
0
7
0
0
7
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _