KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
15.15
Human Site:
S608
Identified Species:
23.81
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S608
T
S
T
R
S
R
N
S
K
T
A
V
S
A
S
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S608
T
S
T
R
S
R
N
S
K
T
A
V
S
A
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S608
T
S
T
R
G
R
S
S
K
A
T
T
S
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S607
I
T
T
R
G
R
S
S
K
A
T
S
S
T
S
Rat
Rattus norvegicus
Q9JIM0
706
80103
S607
I
S
T
R
G
R
S
S
K
A
T
A
S
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
R607
S
C
Q
E
S
P
N
R
S
R
S
S
K
A
S
Chicken
Gallus gallus
Q9IAM7
700
80005
T601
N
T
S
Q
G
S
S
T
S
S
R
T
Y
K
S
Frog
Xenopus laevis
Q9W6K1
711
81112
R605
A
D
Q
P
S
S
G
R
A
T
K
A
T
G
K
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
E519
R
N
T
A
E
E
D
E
E
V
Q
E
A
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
L518
E
L
E
R
F
R
A
L
H
K
H
G
D
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
D615
E
M
E
E
D
E
D
D
P
Q
Y
Y
M
P
P
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
P416
L
S
I
N
F
L
K
P
E
A
L
E
T
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
A606
S
Q
R
S
A
S
A
A
A
S
A
A
F
K
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
R593
T
S
K
P
K
R
V
R
T
A
T
K
K
K
I
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
A628
P
A
K
K
A
A
P
A
K
K
A
A
P
A
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
60
N.A.
46.6
53.3
N.A.
26.6
6.6
13.3
6.6
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
100
N.A.
66.6
N.A.
60
60
N.A.
40
46.6
20
33.3
N.A.
13.3
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
20
P-Site Similarity:
N.A.
N.A.
N.A.
40
20
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
14
7
14
14
14
34
27
27
7
27
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
7
0
14
7
0
0
0
0
7
0
0
% D
% Glu:
14
0
14
14
7
14
0
7
14
0
0
14
0
7
0
% E
% Phe:
0
0
0
0
14
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
27
0
7
0
0
0
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% H
% Ile:
14
0
7
0
0
0
0
0
0
0
0
0
0
7
14
% I
% Lys:
0
0
14
7
7
0
7
0
40
14
7
7
14
20
14
% K
% Leu:
7
7
0
0
0
7
0
7
0
0
7
0
0
7
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
7
7
0
7
0
0
20
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
14
0
7
7
7
7
0
0
0
7
7
7
% P
% Gln:
0
7
14
7
0
0
0
0
0
7
7
0
0
0
0
% Q
% Arg:
7
0
7
40
0
47
0
20
0
7
7
0
0
0
7
% R
% Ser:
14
40
7
7
27
20
27
34
14
14
7
14
34
0
54
% S
% Thr:
27
14
40
0
0
0
0
7
7
20
27
14
14
20
0
% T
% Val:
0
0
0
0
0
0
7
0
0
7
0
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _