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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
14.55
Human Site:
S678
Identified Species:
22.86
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S678
S
S
K
I
M
S
Q
S
Q
V
S
K
G
V
D
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S678
S
S
K
I
M
S
Q
S
Q
V
S
K
G
V
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S678
S
S
K
R
M
S
Q
S
Q
I
A
K
G
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
Q677
S
K
R
M
S
Q
S
Q
T
A
K
G
V
D
F
Rat
Rattus norvegicus
Q9JIM0
706
80103
Q677
S
K
R
M
S
Q
S
Q
T
A
K
G
V
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
Q677
L
S
S
K
R
G
S
Q
S
Q
N
T
K
G
V
Chicken
Gallus gallus
Q9IAM7
700
80005
G671
M
S
S
F
S
K
R
G
S
Q
S
Q
M
S
R
Frog
Xenopus laevis
Q9W6K1
711
81112
S675
S
T
S
Y
S
R
K
S
T
Q
P
Q
S
Q
A
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
G589
S
K
R
G
R
A
R
G
A
A
S
R
S
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
V588
K
G
Q
L
D
V
T
V
S
S
T
R
T
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
T685
R
S
N
K
V
V
S
T
R
Q
I
D
S
D
G
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
T486
Q
L
K
N
R
K
T
T
E
E
H
I
D
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
N676
T
S
K
R
G
R
K
N
E
S
S
S
S
L
N
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
T663
K
T
R
P
A
A
S
T
K
T
A
S
R
R
G
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
R698
P
K
P
K
A
T
S
R
V
A
S
T
R
A
S
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
80
N.A.
6.6
6.6
N.A.
6.6
13.3
13.3
13.3
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
20
20
N.A.
13.3
26.6
33.3
40
N.A.
26.6
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
20
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
60
40
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
14
14
0
0
7
27
14
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
0
7
7
27
20
% D
% Glu:
0
0
0
0
0
0
0
0
14
7
0
0
0
0
7
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
14
% F
% Gly:
0
7
0
7
7
7
0
14
0
0
0
14
20
14
20
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
14
0
0
0
0
0
7
7
7
0
0
0
% I
% Lys:
14
27
34
20
0
14
14
0
7
0
14
20
7
0
0
% K
% Leu:
7
7
0
7
0
0
0
0
0
0
0
0
0
7
0
% L
% Met:
7
0
0
14
20
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
7
7
0
0
0
7
0
0
7
0
0
0
7
% N
% Pro:
7
0
7
7
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
7
0
7
0
0
14
20
20
20
27
0
14
0
7
0
% Q
% Arg:
7
0
27
14
20
14
14
7
7
0
0
14
14
7
14
% R
% Ser:
47
47
20
0
27
20
40
27
20
14
40
14
27
14
7
% S
% Thr:
7
14
0
0
0
7
14
20
20
7
7
14
7
0
0
% T
% Val:
0
0
0
0
7
14
0
7
7
14
0
0
14
20
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _