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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
10.61
Human Site:
S681
Identified Species:
16.67
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S681
I
M
S
Q
S
Q
V
S
K
G
V
D
F
E
S
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S681
I
M
S
Q
S
Q
V
S
K
G
V
D
F
E
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
A681
R
M
S
Q
S
Q
I
A
K
G
V
D
F
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
K680
M
S
Q
S
Q
T
A
K
G
V
D
F
E
S
D
Rat
Rattus norvegicus
Q9JIM0
706
80103
K680
M
S
Q
S
Q
T
A
K
G
V
D
F
E
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
N680
K
R
G
S
Q
S
Q
N
T
K
G
V
D
F
E
Chicken
Gallus gallus
Q9IAM7
700
80005
S674
F
S
K
R
G
S
Q
S
Q
M
S
R
G
V
D
Frog
Xenopus laevis
Q9W6K1
711
81112
P678
Y
S
R
K
S
T
Q
P
Q
S
Q
A
T
K
A
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
S592
G
R
A
R
G
A
A
S
R
S
G
R
G
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
T591
L
D
V
T
V
S
S
T
R
T
S
G
R
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
I688
K
V
V
S
T
R
Q
I
D
S
D
G
F
E
I
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
H489
N
R
K
T
T
E
E
H
I
D
D
E
L
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
S679
R
G
R
K
N
E
S
S
S
S
L
N
R
L
L
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
A666
P
A
A
S
T
K
T
A
S
R
R
G
K
G
R
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
S701
K
A
T
S
R
V
A
S
T
R
A
S
A
R
A
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
80
N.A.
0
0
N.A.
0
6.6
6.6
6.6
N.A.
0
N.A.
13.3
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
6.6
6.6
N.A.
6.6
20
33.3
26.6
N.A.
26.6
N.A.
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
14
0
0
7
27
14
0
0
7
7
7
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
7
7
27
20
7
0
20
% D
% Glu:
0
0
0
0
0
14
7
0
0
0
0
7
14
27
7
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
14
27
7
0
% F
% Gly:
7
7
7
0
14
0
0
0
14
20
14
20
14
14
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% H
% Ile:
14
0
0
0
0
0
7
7
7
0
0
0
0
0
7
% I
% Lys:
20
0
14
14
0
7
0
14
20
7
0
0
7
7
0
% K
% Leu:
7
0
0
0
0
0
0
0
0
0
7
0
7
7
7
% L
% Met:
14
20
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
7
0
0
0
7
0
0
7
0
0
0
7
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% P
% Gln:
0
0
14
20
20
20
27
0
14
0
7
0
0
7
7
% Q
% Arg:
14
20
14
14
7
7
0
0
14
14
7
14
14
7
20
% R
% Ser:
0
27
20
40
27
20
14
40
14
27
14
7
0
14
20
% S
% Thr:
0
0
7
14
20
20
7
7
14
7
0
0
7
0
0
% T
% Val:
0
7
14
0
7
7
14
0
0
14
20
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _