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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
32.73
Human Site:
T450
Identified Species:
51.43
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
T450
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
T450
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
T450
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
T451
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Rat
Rattus norvegicus
Q9JIM0
706
80103
T451
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
T451
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Chicken
Gallus gallus
Q9IAM7
700
80005
T451
K
V
Q
L
S
L
L
T
E
R
R
M
G
E
A
Frog
Xenopus laevis
Q9W6K1
711
81112
T453
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
S383
V
F
N
T
M
R
F
S
Q
K
F
V
D
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
D384
R
L
R
L
L
Y
T
D
E
S
C
M
F
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
E475
K
K
N
N
K
P
K
E
G
K
L
Q
T
E
N
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
L283
E
P
K
H
V
G
L
L
Q
V
R
G
K
A
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
I439
E
S
N
L
K
M
E
I
L
P
V
N
D
L
D
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
V450
E
L
E
V
Q
T
L
V
N
D
L
L
N
K
M
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
F459
K
I
L
P
Q
A
P
F
S
D
A
V
N
Q
F
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
86.6
100
0
N.A.
26.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
86.6
100
33.3
N.A.
40
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
0
7
0
0
7
60
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
14
0
0
14
0
7
% D
% Glu:
20
0
7
0
0
0
7
7
60
0
0
0
0
60
0
% E
% Phe:
0
7
0
0
0
0
7
7
0
0
7
0
7
0
7
% F
% Gly:
0
0
0
0
0
7
0
0
7
0
47
7
54
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
20
7
7
0
14
0
7
0
0
14
0
0
7
14
0
% K
% Leu:
0
14
7
67
7
54
67
7
7
0
14
7
0
7
0
% L
% Met:
0
0
0
0
7
7
0
0
0
0
0
60
0
0
14
% M
% Asn:
47
0
20
7
0
0
0
0
7
0
0
7
14
7
7
% N
% Pro:
0
7
0
7
0
7
7
0
0
7
0
0
0
0
0
% P
% Gln:
0
0
54
0
14
0
0
0
14
0
0
7
0
7
0
% Q
% Arg:
7
0
7
0
0
7
0
0
0
54
14
0
0
0
0
% R
% Ser:
0
7
0
0
54
0
0
7
7
7
0
0
0
0
0
% S
% Thr:
0
0
0
7
0
7
7
54
0
0
0
0
7
0
0
% T
% Val:
7
54
0
7
7
0
0
7
0
7
7
14
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _