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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
24.85
Human Site:
T507
Identified Species:
39.05
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
T507
E
V
R
R
F
R
E
T
R
Q
K
N
T
N
E
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
T507
E
V
R
R
F
R
E
T
R
Q
K
N
T
N
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S507
E
V
R
R
F
R
E
S
R
Q
K
N
T
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S508
E
V
R
R
F
R
E
S
R
Q
R
N
T
N
E
Rat
Rattus norvegicus
Q9JIM0
706
80103
S508
E
V
R
R
F
R
E
S
R
Q
R
N
T
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
T508
E
V
R
R
F
R
E
T
R
R
E
N
S
A
E
Chicken
Gallus gallus
Q9IAM7
700
80005
I498
I
D
A
E
E
E
K
I
D
E
E
V
R
K
F
Frog
Xenopus laevis
Q9W6K1
711
81112
F507
I
D
E
E
V
R
K
F
R
E
T
R
K
T
N
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
A418
D
E
D
V
D
F
E
A
L
F
S
R
P
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
T420
K
V
V
K
R
T
K
T
E
A
V
N
L
D
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
L514
D
Y
F
I
N
Q
P
L
V
D
Q
M
T
V
L
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
D318
Q
D
T
T
L
N
P
D
D
V
K
L
A
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
A482
K
L
A
K
D
S
D
A
K
K
F
E
E
D
D
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
N493
F
I
S
H
E
I
S
N
E
V
G
I
L
S
T
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
F530
Q
A
Q
R
T
K
R
F
K
R
K
P
D
G
W
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
73.3
0
13.3
6.6
N.A.
20
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
93.3
20
26.6
13.3
N.A.
53.3
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
0
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
13.3
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
0
0
0
0
14
0
7
0
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
20
7
0
14
0
7
7
14
7
0
0
7
14
7
% D
% Glu:
40
7
7
14
14
7
47
0
14
14
14
7
7
7
40
% E
% Phe:
7
0
7
0
40
7
0
14
0
7
7
0
0
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
7
0
7
0
7
0
7
0
0
0
7
0
0
0
% I
% Lys:
14
0
0
14
0
7
20
0
14
7
34
0
7
7
14
% K
% Leu:
0
7
0
0
7
0
0
7
7
0
0
7
14
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
7
7
0
7
0
0
0
47
0
34
7
% N
% Pro:
0
0
0
0
0
0
14
0
0
0
0
7
7
0
0
% P
% Gln:
14
0
7
0
0
7
0
0
0
34
7
0
0
0
0
% Q
% Arg:
0
0
40
47
7
47
7
0
47
14
14
14
7
0
0
% R
% Ser:
0
0
7
0
0
7
7
20
0
0
7
0
7
7
7
% S
% Thr:
0
0
7
7
7
7
0
27
0
0
7
0
40
14
7
% T
% Val:
0
47
7
7
7
0
0
0
7
14
7
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _