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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
11.52
Human Site:
T662
Identified Species:
18.1
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
T662
I
F
P
T
T
S
K
T
D
Q
R
W
S
S
T
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
T662
I
F
P
T
T
S
K
T
D
Q
R
W
S
S
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
T662
I
F
P
T
T
S
K
T
E
Q
R
W
S
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
D661
F
P
T
N
S
R
A
D
Q
R
W
S
G
T
T
Rat
Rattus norvegicus
Q9JIM0
706
80103
D661
F
P
T
S
S
R
A
D
Q
R
W
S
G
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
P661
D
M
E
D
D
L
F
P
A
S
S
K
V
D
Q
Chicken
Gallus gallus
Q9IAM7
700
80005
S655
E
S
P
I
S
L
S
S
K
T
N
Q
R
S
S
Frog
Xenopus laevis
Q9W6K1
711
81112
I659
S
F
T
P
S
S
V
I
E
S
R
R
T
S
S
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
S573
V
R
G
R
G
R
G
S
R
G
G
R
D
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
A572
R
G
T
A
R
T
R
A
G
A
T
A
A
T
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
G669
G
R
G
A
R
G
A
G
A
S
R
E
T
T
R
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
K470
E
A
I
Q
A
L
V
K
H
Q
L
S
Q
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
K660
R
K
R
P
A
T
T
K
R
G
R
G
R
G
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
L647
E
E
D
A
S
Y
G
L
L
N
G
R
K
T
K
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
D682
E
D
V
I
M
E
D
D
E
E
D
P
P
A
P
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
93.3
N.A.
6.6
0
N.A.
0
13.3
26.6
0
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
26.6
26.6
N.A.
0
33.3
53.3
20
N.A.
26.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
20
14
0
20
7
14
7
0
7
7
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
7
7
0
7
20
14
0
7
0
7
7
0
% D
% Glu:
27
7
7
0
0
7
0
0
20
7
0
7
0
0
0
% E
% Phe:
14
27
0
0
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
14
0
7
7
14
7
7
14
14
7
14
7
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
20
0
7
14
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
0
0
20
14
7
0
0
7
7
0
7
% K
% Leu:
0
0
0
0
0
20
0
7
7
0
7
0
0
0
0
% L
% Met:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
7
7
0
0
0
0
% N
% Pro:
0
14
27
14
0
0
0
7
0
0
0
7
7
7
7
% P
% Gln:
0
0
0
7
0
0
0
0
14
27
0
7
7
0
14
% Q
% Arg:
14
14
7
7
14
20
7
0
14
14
40
20
14
0
14
% R
% Ser:
7
7
0
7
34
27
7
14
0
20
7
20
20
34
27
% S
% Thr:
0
0
27
20
20
14
7
20
0
7
7
0
14
40
27
% T
% Val:
7
0
7
0
0
0
14
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
14
20
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _