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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
32.12
Human Site:
Y436
Identified Species:
50.48
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
Y436
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
Y436
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
Y436
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
Y437
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Rat
Rattus norvegicus
Q9JIM0
706
80103
Y437
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
Y437
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Chicken
Gallus gallus
Q9IAM7
700
80005
Y437
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
K
Frog
Xenopus laevis
Q9W6K1
711
81112
Y439
V
E
D
L
V
K
E
Y
F
K
T
A
E
K
N
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
D369
P
L
I
R
L
R
V
D
Y
S
G
G
F
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
Q370
Q
H
T
G
H
P
K
Q
P
T
L
P
L
I
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
A461
Y
E
N
V
V
A
N
A
V
D
M
V
F
I
K
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
S269
P
G
S
S
I
A
T
S
L
S
P
G
E
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
N425
P
E
E
L
N
Q
Q
N
I
E
A
L
V
A
E
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
L436
S
D
R
D
V
E
K
L
F
S
E
S
G
G
E
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
F445
V
D
N
L
V
Q
E
F
F
A
Q
Q
S
L
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
86.6
0
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
100
26.6
N.A.
6.6
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
40
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
14
0
7
0
7
7
54
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
54
7
0
0
0
7
0
7
0
0
0
0
0
% D
% Glu:
0
67
7
0
0
7
14
0
0
7
7
0
60
7
20
% E
% Phe:
0
0
0
0
0
0
0
7
67
0
0
0
14
0
0
% F
% Gly:
0
7
0
7
0
0
0
0
0
0
7
14
7
7
0
% G
% His:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
7
0
0
0
7
0
0
0
0
14
0
% I
% Lys:
0
0
0
0
0
54
14
0
0
7
0
0
0
54
20
% K
% Leu:
0
7
0
67
7
0
0
7
7
0
7
7
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
14
0
7
0
7
7
0
0
0
0
0
0
47
% N
% Pro:
20
0
0
0
0
7
0
0
7
0
7
7
0
0
0
% P
% Gln:
7
0
0
0
0
14
54
7
0
47
7
7
0
0
0
% Q
% Arg:
0
0
7
7
0
7
0
0
0
0
0
0
0
0
7
% R
% Ser:
7
0
7
7
0
0
0
7
0
20
0
7
7
0
0
% S
% Thr:
0
0
7
0
0
0
7
0
0
7
54
0
0
0
0
% T
% Val:
60
0
0
7
74
0
7
0
7
0
0
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
54
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _