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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH3A
All Species:
48.48
Human Site:
S109
Identified Species:
71.11
UniProt:
P50213
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50213
NP_005521.1
366
39592
S109
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Chimpanzee
Pan troglodytes
XP_510524
341
36949
A97
R
K
T
F
D
L
Y
A
N
V
R
P
C
V
S
Rhesus Macaque
Macaca mulatta
XP_001106839
288
31390
A44
R
K
T
F
D
L
Y
A
N
V
R
P
C
V
S
Dog
Lupus familis
XP_536213
366
39739
S109
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9D6R2
366
39620
S109
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Rat
Rattus norvegicus
Q99NA5
366
39595
S109
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513325
359
38883
S102
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Chicken
Gallus gallus
XP_413748
397
43524
S132
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Frog
Xenopus laevis
NP_001085990
368
40203
S111
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Zebra Danio
Brachydanio rerio
NP_957245
365
39965
S108
P
I
A
A
G
H
P
S
M
N
L
L
L
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VWH4
377
40826
S125
P
V
G
K
G
H
R
S
L
N
L
A
L
R
K
Honey Bee
Apis mellifera
XP_392811
358
39117
A105
G
H
R
S
L
N
L
A
L
R
K
E
F
N
L
Nematode Worm
Caenorhab. elegans
Q93714
358
38448
S102
P
I
G
K
G
H
R
S
L
N
L
A
V
R
K
Sea Urchin
Strong. purpuratus
XP_792505
368
39889
S104
P
I
G
K
G
H
M
S
L
N
L
A
L
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q945K7
374
40606
S121
P
I
G
K
G
H
R
S
L
N
L
T
L
R
K
Baker's Yeast
Sacchar. cerevisiae
P28241
369
39721
S113
P
I
G
K
G
H
R
S
L
N
L
T
L
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
78.4
97.5
N.A.
97.5
97.2
N.A.
93.7
81.8
85
84.9
N.A.
67.6
68.3
68.3
69.8
Protein Similarity:
100
92.9
78.6
98.6
N.A.
98.6
98.6
N.A.
95
85.6
90.7
91.8
N.A.
79.8
80.5
77
80.4
P-Site Identity:
100
0
0
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
60
0
60
66.6
P-Site Similarity:
100
6.6
6.6
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
26.6
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
54
52
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
71.9
66.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
50
50
0
0
0
19
0
0
0
19
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% C
% Asp:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% E
% Phe:
0
0
0
13
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
7
0
32
0
82
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
0
0
82
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
75
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
13
0
32
0
0
0
0
0
0
7
0
0
0
82
% K
% Leu:
0
0
0
0
7
13
7
0
38
0
82
50
75
0
7
% L
% Met:
0
0
0
0
0
0
7
0
50
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
13
82
0
0
0
7
0
% N
% Pro:
82
0
0
0
0
0
50
0
0
0
0
13
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
13
0
7
0
0
0
25
0
0
7
13
0
0
82
0
% R
% Ser:
0
0
0
7
0
0
0
82
0
0
0
0
0
0
13
% S
% Thr:
0
0
13
0
0
0
0
0
0
0
0
13
0
0
0
% T
% Val:
0
7
0
0
0
0
0
0
0
13
0
0
7
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _