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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDH3A All Species: 51.21
Human Site: Y137 Identified Species: 75.11
UniProt: P50213 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P50213 NP_005521.1 366 39592 Y137 I E G Y K T P Y T D V N I V T
Chimpanzee Pan troglodytes XP_510524 341 36949 E125 V T I R E N T E G E Y S G I E
Rhesus Macaque Macaca mulatta XP_001106839 288 31390 E72 V T I R E N T E G E Y S G I E
Dog Lupus familis XP_536213 366 39739 Y137 I E G Y K T P Y T D V N I V T
Cat Felis silvestris
Mouse Mus musculus Q9D6R2 366 39620 Y137 I E G Y K T P Y T D V N I V T
Rat Rattus norvegicus Q99NA5 366 39595 Y137 I E G Y K T P Y T D V N I V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513325 359 38883 Y130 I E G Y K T P Y T D V N I V T
Chicken Gallus gallus XP_413748 397 43524 Y160 I E G Y K T P Y T D V N I V T
Frog Xenopus laevis NP_001085990 368 40203 Y139 I E G Y R T P Y T D V D L V T
Zebra Danio Brachydanio rerio NP_957245 365 39965 Y136 I E G Y K T P Y T D V D L V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VWH4 377 40826 Y153 L E G Y K T L Y D D V D V V T
Honey Bee Apis mellifera XP_392811 358 39117 D133 K T L Y D N V D V V T I R E N
Nematode Worm Caenorhab. elegans Q93714 358 38448 Y130 L E G H K T L Y D N V D V V T
Sea Urchin Strong. purpuratus XP_792505 368 39889 Y132 L E G Y K T P Y D D V D L V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q945K7 374 40606 Y149 L P G Y K T R Y D D V D L I T
Baker's Yeast Sacchar. cerevisiae P28241 369 39721 Y141 I E G F K T T Y E N V D L V L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.3 78.4 97.5 N.A. 97.5 97.2 N.A. 93.7 81.8 85 84.9 N.A. 67.6 68.3 68.3 69.8
Protein Similarity: 100 92.9 78.6 98.6 N.A. 98.6 98.6 N.A. 95 85.6 90.7 91.8 N.A. 79.8 80.5 77 80.4
P-Site Identity: 100 0 0 100 N.A. 100 100 N.A. 100 100 80 86.6 N.A. 66.6 6.6 53.3 73.3
P-Site Similarity: 100 33.3 33.3 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 86.6 6.6 86.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 54 52 N.A.
Protein Similarity: N.A. N.A. N.A. 71.9 66.9 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 7 25 69 0 44 0 0 0 % D
% Glu: 0 75 0 0 13 0 0 13 7 13 0 0 0 7 13 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 82 0 0 0 0 0 13 0 0 0 13 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 57 0 13 0 0 0 0 0 0 0 0 7 38 19 0 % I
% Lys: 7 0 0 0 75 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 25 0 7 0 0 0 13 0 0 0 0 0 32 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 19 0 0 0 13 0 38 0 0 7 % N
% Pro: 0 7 0 0 0 0 57 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 13 7 0 7 0 0 0 0 0 7 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 13 0 0 0 % S
% Thr: 0 19 0 0 0 82 19 0 50 0 7 0 0 0 75 % T
% Val: 13 0 0 0 0 0 7 0 7 7 82 0 13 75 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 75 0 0 0 82 0 0 13 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _