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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR6
All Species:
7.58
Human Site:
S378
Identified Species:
13.89
UniProt:
P50406
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50406
NP_000862.1
440
46954
S378
P
L
P
L
P
P
D
S
D
S
D
S
D
A
G
Chimpanzee
Pan troglodytes
Q5IS65
440
46934
S378
P
L
P
L
P
P
D
S
D
S
D
S
D
A
G
Rhesus Macaque
Macaca mulatta
O77680
446
49274
V395
V
Y
L
I
P
H
A
V
G
S
S
E
D
L
K
Dog
Lupus familis
XP_544528
368
39725
G319
S
G
S
G
G
S
S
G
Q
Q
R
T
A
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1C8
440
46980
P378
V
L
P
L
P
L
P
P
N
S
D
S
D
S
A
Rat
Rattus norvegicus
P31388
436
46904
I379
C
L
C
R
Q
T
Q
I
Q
T
P
L
Q
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515752
436
47620
S384
T
L
P
G
E
T
D
S
G
D
S
V
L
Q
V
Chicken
Gallus gallus
XP_427576
433
47582
T381
V
L
T
L
Q
A
E
T
D
S
V
V
S
E
V
Frog
Xenopus laevis
P42289
451
50531
P385
Q
E
P
K
G
S
I
P
N
E
C
N
L
V
Y
Zebra Danio
Brachydanio rerio
XP_696681
471
51696
P422
S
L
R
N
S
G
E
P
Q
L
P
S
E
P
P
Tiger Blowfish
Takifugu rubipres
P53454
463
51077
R389
V
P
G
P
G
A
H
R
L
V
A
P
L
P
Q
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001011595
402
44536
Q350
G
A
R
A
R
G
N
Q
P
S
T
S
E
C
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784371
461
52045
K403
V
L
C
R
C
W
D
K
R
P
R
K
R
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
29.8
69.3
N.A.
88.4
76.1
N.A.
65.6
61.1
29.2
51.5
33
N.A.
31.3
N.A.
31.6
Protein Similarity:
100
99.7
47.9
72.2
N.A.
91.5
80
N.A.
74.7
71.1
46.7
60
48.6
N.A.
46.8
N.A.
47.9
P-Site Identity:
100
100
20
0
N.A.
53.3
6.6
N.A.
26.6
26.6
6.6
13.3
0
N.A.
20
N.A.
13.3
P-Site Similarity:
100
100
26.6
6.6
N.A.
66.6
13.3
N.A.
26.6
40
20
26.6
0
N.A.
33.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
16
8
0
0
0
8
0
8
16
16
% A
% Cys:
8
0
16
0
8
0
0
0
0
0
8
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
31
0
24
8
24
0
31
0
0
% D
% Glu:
0
8
0
0
8
0
16
0
0
8
0
8
16
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
8
16
24
16
0
8
16
0
0
0
0
8
24
% G
% His:
0
0
0
0
0
8
8
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
8
0
0
8
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
8
0
0
0
8
0
0
8
% K
% Leu:
0
62
8
31
0
8
0
0
8
8
0
8
24
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
16
0
0
8
0
0
0
% N
% Pro:
16
8
39
8
31
16
8
24
8
8
16
8
0
16
16
% P
% Gln:
8
0
0
0
16
0
8
8
24
8
0
0
8
16
8
% Q
% Arg:
0
0
16
16
8
0
0
8
8
0
16
0
8
0
8
% R
% Ser:
16
0
8
0
8
16
8
24
0
47
16
39
8
8
0
% S
% Thr:
8
0
8
0
0
16
0
8
0
8
8
8
0
0
0
% T
% Val:
39
0
0
0
0
0
0
8
0
8
8
16
0
8
16
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _