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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP2
All Species:
21.52
Human Site:
S60
Identified Species:
31.56
UniProt:
P50579
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50579
NP_006829.1
478
52892
S60
E
Q
E
P
D
K
E
S
G
A
S
V
D
E
V
Chimpanzee
Pan troglodytes
XP_509279
506
55752
S60
E
Q
E
P
D
K
E
S
G
A
S
V
D
E
V
Rhesus Macaque
Macaca mulatta
XP_001107008
478
52846
S60
E
Q
E
P
D
K
E
S
G
A
S
V
D
E
V
Dog
Lupus familis
XP_866154
477
52787
S59
Q
Q
E
P
D
K
E
S
G
A
S
V
D
E
V
Cat
Felis silvestris
Mouse
Mus musculus
O08663
478
52903
S60
Q
Q
E
L
D
K
E
S
G
A
L
V
D
E
V
Rat
Rattus norvegicus
P38062
478
53033
S60
Q
Q
E
L
D
K
E
S
G
T
S
V
D
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514935
562
60510
P140
S
A
A
P
G
A
E
P
G
A
R
S
P
E
R
Chicken
Gallus gallus
NP_001006233
479
53005
M61
G
Q
E
T
D
K
E
M
E
G
A
L
D
D
V
Frog
Xenopus laevis
NP_001080472
462
51462
E56
E
E
I
T
A
Q
L
E
K
Q
T
L
D
N
K
Zebra Danio
Brachydanio rerio
NP_955934
476
53163
G59
V
E
N
H
D
G
E
G
D
T
D
I
A
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477373
448
49786
G55
D
E
E
L
T
T
N
G
D
A
K
P
A
T
P
Honey Bee
Apis mellifera
XP_624161
474
52546
E61
S
A
D
V
P
E
G
E
E
E
K
T
K
N
D
Nematode Worm
Caenorhab. elegans
P50581
182
20674
Sea Urchin
Strong. purpuratus
XP_780497
508
56248
V61
G
V
N
E
T
G
E
V
N
G
E
V
E
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q56Y85
439
49041
D49
E
D
G
Q
E
E
N
D
G
E
E
G
S
K
A
Baker's Yeast
Sacchar. cerevisiae
P38174
421
47484
K31
V
E
Q
Q
D
Q
A
K
A
D
E
S
D
P
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
99.1
97.9
N.A.
94.9
94.9
N.A.
73.1
86.8
80.7
78.6
N.A.
62.7
63.5
22.7
67.3
Protein Similarity:
100
94.4
99.3
98.9
N.A.
96.6
97
N.A.
78.1
93.1
88
87.4
N.A.
75.9
79
29.2
76.7
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
33.3
46.6
13.3
20
N.A.
13.3
0
0
20
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
33.3
66.6
40
40
N.A.
26.6
13.3
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
61.5
48.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
73.2
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
7
0
7
7
7
0
7
44
7
0
13
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
0
57
0
0
7
13
7
7
0
57
7
7
% D
% Glu:
32
25
50
7
7
13
63
13
13
13
19
0
7
44
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
13
0
7
0
7
13
7
13
50
13
0
7
0
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
0
0
0
0
44
0
7
7
0
13
0
7
19
7
% K
% Leu:
0
0
0
19
0
0
7
0
0
0
7
13
0
0
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
13
0
0
0
13
0
7
0
0
0
0
13
0
% N
% Pro:
0
0
0
32
7
0
0
7
0
0
0
7
7
7
7
% P
% Gln:
19
44
7
13
0
13
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% R
% Ser:
13
0
0
0
0
0
0
38
0
0
32
13
7
0
0
% S
% Thr:
0
0
0
13
13
7
0
0
0
13
7
7
0
7
0
% T
% Val:
13
7
0
7
0
0
0
7
0
0
0
44
0
0
63
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _