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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP2
All Species:
48.79
Human Site:
T284
Identified Species:
71.56
UniProt:
P50579
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50579
NP_006829.1
478
52892
T284
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Chimpanzee
Pan troglodytes
XP_509279
506
55752
T312
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Rhesus Macaque
Macaca mulatta
XP_001107008
478
52846
T284
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Dog
Lupus familis
XP_866154
477
52787
T283
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Cat
Felis silvestris
Mouse
Mus musculus
O08663
478
52903
T284
L
T
A
V
K
D
A
T
N
T
G
I
K
C
A
Rat
Rattus norvegicus
P38062
478
53033
T284
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514935
562
60510
T368
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Chicken
Gallus gallus
NP_001006233
479
53005
T285
L
E
A
V
K
D
A
T
N
T
G
I
K
C
A
Frog
Xenopus laevis
NP_001080472
462
51462
T268
L
E
A
V
K
D
A
T
N
T
G
I
R
C
S
Zebra Danio
Brachydanio rerio
NP_955934
476
53163
T282
L
E
A
V
K
D
A
T
N
T
G
I
K
C
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477373
448
49786
I263
T
G
I
R
E
A
G
I
D
V
R
L
C
D
I
Honey Bee
Apis mellifera
XP_624161
474
52546
T280
I
E
A
V
R
D
A
T
N
T
G
I
K
A
A
Nematode Worm
Caenorhab. elegans
P50581
182
20674
Sea Urchin
Strong. purpuratus
XP_780497
508
56248
T314
L
A
A
V
K
D
A
T
N
T
G
I
K
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q56Y85
439
49041
R257
K
E
A
G
I
D
V
R
L
C
D
I
G
A
A
Baker's Yeast
Sacchar. cerevisiae
P38174
421
47484
R239
K
E
A
G
I
D
V
R
L
T
D
I
G
E
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
99.1
97.9
N.A.
94.9
94.9
N.A.
73.1
86.8
80.7
78.6
N.A.
62.7
63.5
22.7
67.3
Protein Similarity:
100
94.4
99.3
98.9
N.A.
96.6
97
N.A.
78.1
93.1
88
87.4
N.A.
75.9
79
29.2
76.7
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
100
93.3
80
93.3
N.A.
0
73.3
0
86.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
100
100
100
100
N.A.
20
93.3
0
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
61.5
48.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
73.2
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
88
0
0
7
75
0
0
0
0
0
0
13
82
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
7
63
0
% C
% Asp:
0
0
0
0
0
88
0
0
7
0
13
0
0
7
0
% D
% Glu:
0
38
0
0
7
0
0
0
0
0
0
0
0
13
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
13
0
0
7
0
0
0
75
0
13
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
0
13
0
0
7
0
0
0
88
0
0
7
% I
% Lys:
13
38
0
0
69
0
0
0
0
0
0
0
69
0
0
% K
% Leu:
69
0
0
0
0
0
0
0
13
0
0
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
75
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
7
0
0
13
0
0
7
0
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% S
% Thr:
7
7
0
0
0
0
0
75
0
82
0
0
0
0
0
% T
% Val:
0
0
0
75
0
0
13
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _