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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP2
All Species:
55.45
Human Site:
Y383
Identified Species:
81.33
UniProt:
P50579
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50579
NP_006829.1
478
52892
Y383
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Chimpanzee
Pan troglodytes
XP_509279
506
55752
Y411
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Rhesus Macaque
Macaca mulatta
XP_001107008
478
52846
Y383
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Dog
Lupus familis
XP_866154
477
52787
Y382
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Cat
Felis silvestris
Mouse
Mus musculus
O08663
478
52903
Y383
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Rat
Rattus norvegicus
P38062
478
53033
Y383
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514935
562
60510
Y467
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Chicken
Gallus gallus
NP_001006233
479
53005
Y384
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Frog
Xenopus laevis
NP_001080472
462
51462
Y367
D
D
M
E
C
S
H
Y
M
K
N
F
D
L
G
Zebra Danio
Brachydanio rerio
NP_955934
476
53163
Y381
D
D
M
E
C
S
H
Y
M
K
N
F
E
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477373
448
49786
Y353
D
D
M
D
C
S
H
Y
M
K
N
F
D
L
P
Honey Bee
Apis mellifera
XP_624161
474
52546
Y379
D
D
L
D
C
S
H
Y
M
K
S
F
D
A
G
Nematode Worm
Caenorhab. elegans
P50581
182
20674
H90
S
T
G
K
G
Y
F
H
D
D
M
E
T
S
H
Sea Urchin
Strong. purpuratus
XP_780497
508
56248
Y413
D
D
M
E
C
S
H
Y
M
K
N
F
E
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q56Y85
439
49041
N347
E
C
S
H
Y
M
K
N
F
D
A
G
H
V
P
Baker's Yeast
Sacchar. cerevisiae
P38174
421
47484
S329
E
V
S
H
Y
A
R
S
A
E
D
H
Q
V
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
99.1
97.9
N.A.
94.9
94.9
N.A.
73.1
86.8
80.7
78.6
N.A.
62.7
63.5
22.7
67.3
Protein Similarity:
100
94.4
99.3
98.9
N.A.
96.6
97
N.A.
78.1
93.1
88
87.4
N.A.
75.9
79
29.2
76.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
80
73.3
0
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
61.5
48.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
73.2
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
7
0
7
0
0
7
0
% A
% Cys:
0
7
0
0
82
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
82
82
0
13
0
0
0
0
7
13
7
0
69
0
0
% D
% Glu:
13
0
0
69
0
0
0
0
0
7
0
7
13
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
7
0
0
82
0
0
0
% F
% Gly:
0
0
7
0
7
0
0
0
0
0
0
7
0
0
75
% G
% His:
0
0
0
13
0
0
82
7
0
0
0
7
7
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
7
0
0
7
0
0
82
0
0
0
0
0
% K
% Leu:
0
0
7
0
0
0
0
0
0
0
0
0
0
13
0
% L
% Met:
0
0
75
0
0
7
0
0
82
0
7
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
75
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
7
0
13
0
0
82
0
7
0
0
7
0
0
7
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
0
7
0
0
0
0
0
0
0
0
0
0
0
75
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
13
7
0
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _