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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METAP2 All Species: 53.03
Human Site: Y428 Identified Species: 77.78
UniProt: P50579 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P50579 NP_006829.1 478 52892 Y428 D R L G E S K Y L M A L K N L
Chimpanzee Pan troglodytes XP_509279 506 55752 Y456 D R L G E S K Y L M A L K N L
Rhesus Macaque Macaca mulatta XP_001107008 478 52846 Y428 D R L G E S K Y L M A L K N L
Dog Lupus familis XP_866154 477 52787 Y427 D R L G E S K Y L M A L K N L
Cat Felis silvestris
Mouse Mus musculus O08663 478 52903 Y428 D R L G E S K Y L M A L K N L
Rat Rattus norvegicus P38062 478 53033 Y428 D R L G E S K Y L M A L K N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514935 562 60510 Y512 D R L G E S K Y L M A L K N L
Chicken Gallus gallus NP_001006233 479 53005 Y429 D R L G E S K Y L M A L K N L
Frog Xenopus laevis NP_001080472 462 51462 Y412 D R L G E S K Y L M A L K N L
Zebra Danio Brachydanio rerio NP_955934 476 53163 Y426 D R L G E T K Y L M A L K N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477373 448 49786 Y398 D R A G A T K Y Q M A L K D L
Honey Bee Apis mellifera XP_624161 474 52546 Y424 D R V G C T K Y Q M A L K D L
Nematode Worm Caenorhab. elegans P50581 182 20674 R134 F A T L A F C R C W I D R L E
Sea Urchin Strong. purpuratus XP_780497 508 56248 Y458 D R L G E T K Y L M A L K N L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q56Y85 439 49041 M391 I G E T K Y L M A L K N L C D
Baker's Yeast Sacchar. cerevisiae P38174 421 47484 F373 L G Q E K Y L F A L N N L V R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.4 99.1 97.9 N.A. 94.9 94.9 N.A. 73.1 86.8 80.7 78.6 N.A. 62.7 63.5 22.7 67.3
Protein Similarity: 100 94.4 99.3 98.9 N.A. 96.6 97 N.A. 78.1 93.1 88 87.4 N.A. 75.9 79 29.2 76.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 93.3 N.A. 66.6 66.6 0 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 80 86.6 6.6 100
Percent
Protein Identity: N.A. N.A. N.A. 61.5 48.7 N.A.
Protein Similarity: N.A. N.A. N.A. 73.2 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 13 0 0 0 13 0 82 0 0 0 0 % A
% Cys: 0 0 0 0 7 0 7 0 7 0 0 0 0 7 0 % C
% Asp: 82 0 0 0 0 0 0 0 0 0 0 7 0 13 7 % D
% Glu: 0 0 7 7 69 0 0 0 0 0 0 0 0 0 7 % E
% Phe: 7 0 0 0 0 7 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 13 0 82 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % I
% Lys: 0 0 0 0 13 0 82 0 0 0 7 0 82 0 0 % K
% Leu: 7 0 69 7 0 0 13 0 69 13 0 82 13 7 82 % L
% Met: 0 0 0 0 0 0 0 7 0 82 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 7 13 0 69 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 13 0 0 0 0 0 0 % Q
% Arg: 0 82 0 0 0 0 0 7 0 0 0 0 7 0 7 % R
% Ser: 0 0 0 0 0 57 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 7 7 0 25 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 13 0 82 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _