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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK7
All Species:
39.7
Human Site:
T223
Identified Species:
58.22
UniProt:
P50613
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50613
NP_001790.1
346
39038
T223
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Chimpanzee
Pan troglodytes
XP_518193
305
34323
E194
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
Rhesus Macaque
Macaca mulatta
XP_001092242
346
39008
T223
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Dog
Lupus familis
XP_850424
354
39795
T231
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q03147
346
38950
T223
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Rat
Rattus norvegicus
P51952
329
37122
T215
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506541
324
36280
T201
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Chicken
Gallus gallus
P13863
303
34670
I193
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
Frog
Xenopus laevis
P20911
352
39672
T229
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
Zebra Danio
Brachydanio rerio
A8WIP6
344
39006
C214
E
N
D
I
E
Q
L
C
C
V
L
R
V
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511044
353
39655
T223
D
S
D
L
D
Q
L
T
R
I
F
S
T
L
G
Honey Bee
Apis mellifera
XP_395800
321
36188
T202
E
S
D
L
D
Q
L
T
R
I
F
Q
T
L
G
Nematode Worm
Caenorhab. elegans
P34556
332
38277
L221
E
M
A
T
K
K
P
L
F
Q
G
D
S
E
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
D186
R
Q
Y
S
T
P
V
D
V
W
S
V
G
C
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LMT0
391
44511
S220
N
S
D
I
D
Q
L
S
K
I
F
A
A
F
G
Baker's Yeast
Sacchar. cerevisiae
P06242
306
35228
E197
S
V
G
V
I
F
A
E
L
M
L
R
I
P
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
99.7
92.6
N.A.
95
91
N.A.
87.5
39.8
85.2
42.2
N.A.
65.7
63.8
39.3
N.A.
Protein Similarity:
100
88.1
99.7
95.4
N.A.
96.8
92.4
N.A.
88.7
56.3
90.3
59.5
N.A.
78.4
75.1
57.5
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
100
6.6
100
33.3
N.A.
93.3
86.6
0
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
6.6
100
66.6
N.A.
93.3
100
26.6
N.A.
Percent
Protein Identity:
N.A.
39.3
N.A.
49.1
41
N.A.
Protein Similarity:
N.A.
57.8
N.A.
65.2
60.6
N.A.
P-Site Identity:
N.A.
0
N.A.
53.3
0
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
80
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
7
0
0
7
0
7
13
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
7
0
0
0
0
13
0
% C
% Asp:
57
0
69
0
63
0
0
7
0
0
0
13
0
0
0
% D
% Glu:
19
0
0
0
7
0
7
13
0
0
7
44
0
7
0
% E
% Phe:
0
0
0
0
0
7
0
0
13
0
63
0
0
7
0
% F
% Gly:
0
0
13
0
0
7
0
0
0
0
7
0
7
0
69
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
13
13
0
0
7
0
63
0
0
7
0
13
% I
% Lys:
0
0
0
0
7
7
0
0
7
0
0
0
0
0
7
% K
% Leu:
0
7
0
57
0
0
69
7
7
0
13
7
0
63
0
% L
% Met:
0
7
0
0
0
0
0
0
0
7
0
0
7
0
0
% M
% Asn:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
7
7
0
0
0
7
0
0
7
0
% P
% Gln:
0
7
0
0
0
69
0
0
7
7
0
7
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
57
0
0
13
0
0
0
% R
% Ser:
7
63
0
13
0
0
0
7
0
0
7
7
7
0
7
% S
% Thr:
7
0
0
13
7
7
7
57
0
0
0
0
57
7
0
% T
% Val:
0
7
0
7
0
0
7
0
7
7
0
7
7
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
13
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _