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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK9
All Species:
25.76
Human Site:
Y259
Identified Species:
37.78
UniProt:
P50750
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50750
NP_001252.1
372
42778
Y259
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094502
352
40482
Y239
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
Dog
Lupus familis
XP_548446
534
59045
Y421
V
W
P
N
V
D
K
Y
E
L
F
E
K
L
D
Cat
Felis silvestris
Mouse
Mus musculus
NP_570930
372
42743
Y259
V
W
P
N
V
D
K
Y
E
L
F
E
K
L
E
Rat
Rattus norvegicus
Q641Z4
372
42743
Y259
V
W
P
N
V
D
K
Y
E
L
F
E
K
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520593
314
36161
R211
Y
Q
K
L
D
L
P
R
G
Q
K
R
K
V
K
Chicken
Gallus gallus
Q5ZKN1
372
42784
Y259
V
W
P
N
V
D
K
Y
E
L
Y
Q
K
L
E
Frog
Xenopus laevis
Q4V862
376
43205
Y263
V
W
P
N
V
D
K
Y
E
L
Y
Q
K
L
E
Zebra Danio
Brachydanio rerio
NP_997756
393
45129
K280
V
W
P
G
V
D
K
K
Y
E
L
Y
Q
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477226
404
46768
L291
V
W
P
G
V
E
E
L
E
L
Y
K
S
I
E
Honey Bee
Apis mellifera
XP_396015
382
43973
L265
V
W
P
G
V
E
N
L
E
L
F
N
K
M
D
Nematode Worm
Caenorhab. elegans
Q9TVL3
478
53575
M329
V
W
P
N
C
V
N
M
P
L
W
S
A
M
S
Sea Urchin
Strong. purpuratus
XP_798269
410
46418
L288
V
W
P
G
L
E
K
L
E
L
S
N
T
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LFT8
505
56711
M271
L
W
P
G
V
S
K
M
P
W
F
N
N
F
K
Baker's Yeast
Sacchar. cerevisiae
P23293
657
74221
L313
D
W
A
V
A
R
Y
L
P
G
A
E
L
T
T
Red Bread Mold
Neurospora crassa
Q871M9
545
61347
L274
T
M
P
G
W
R
T
L
P
G
G
Q
A
F
S
Conservation
Percent
Protein Identity:
100
N.A.
92.4
68.5
N.A.
98.6
98.6
N.A.
77.9
93
89.3
85.5
N.A.
66
72.7
43.3
67.3
Protein Similarity:
100
N.A.
93.5
69.4
N.A.
99.7
99.7
N.A.
80.3
95.4
94.1
89.5
N.A.
75.9
83.2
56.4
75.8
P-Site Identity:
100
N.A.
100
80
N.A.
86.6
86.6
N.A.
6.6
86.6
86.6
33.3
N.A.
53.3
53.3
40
46.6
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
20
93.3
93.3
40
N.A.
73.3
80
53.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
36
25.2
31.7
Protein Similarity:
N.A.
N.A.
N.A.
51
39.4
45.6
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
0
0
0
0
7
0
13
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
7
50
0
0
0
0
0
0
0
0
13
% D
% Glu:
0
0
0
0
0
19
7
0
63
7
0
38
0
0
50
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
32
0
0
13
0
% F
% Gly:
0
0
0
38
0
0
0
0
7
13
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
0
7
0
0
0
50
7
0
0
7
7
57
7
13
% K
% Leu:
7
0
0
7
7
7
0
32
0
69
7
0
7
50
0
% L
% Met:
0
7
0
0
0
0
0
13
0
0
0
0
0
13
7
% M
% Asn:
0
0
0
50
0
0
25
0
0
0
0
19
7
0
0
% N
% Pro:
0
0
88
0
0
0
7
0
25
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
7
0
19
7
0
0
% Q
% Arg:
0
0
0
0
0
13
0
7
0
0
0
7
0
0
0
% R
% Ser:
0
0
0
0
0
7
0
0
0
0
7
7
7
0
13
% S
% Thr:
7
0
0
0
0
0
7
0
0
0
0
0
7
7
7
% T
% Val:
75
0
0
7
69
7
0
0
0
0
0
0
0
7
0
% V
% Trp:
0
88
0
0
7
0
0
0
0
7
7
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
7
44
7
0
32
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _