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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAPOLA All Species: 7.27
Human Site: S591 Identified Species: 14.55
UniProt: P51003 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.45
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51003 NP_116021.2 745 82843 S591 S E S S G G T S S E S I P Q T
Chimpanzee Pan troglodytes XP_515496 714 80108 T558 D S P S V G E T E R N S A E P
Rhesus Macaque Macaca mulatta XP_001101831 825 90125 S539 S E S S G G T S S E S I P Q T
Dog Lupus familis XP_537551 812 90509 E658 V P Q V N S T E S S G G T S S
Cat Felis silvestris
Mouse Mus musculus Q61183 739 82291 E585 V P Q A N S S E S P G G P S S
Rat Rattus norvegicus NP_001101526 739 82082 E585 V P Q A N S S E S P G G P S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511509 736 82218 E582 V P Q I N S I E S S G G S S S
Chicken Gallus gallus XP_421352 737 82879 E584 V P Q T N S S E S S G G S S N
Frog Xenopus laevis P51004 715 80169 N561 T D V M V P Q N N S T E N L G
Zebra Danio Brachydanio rerio NP_991321 723 80246 T570 L Q G K T E A T G E N T H L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393202 615 69546 V463 T Y D I K S F V D S I L R Q A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29468 568 64534 P416 F E S S Y C C P T E D D Y E M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.8 78.4 89.7 N.A. 95.5 95 N.A. 95.5 89.9 80.1 70.3 N.A. N.A. 49.7 N.A. N.A.
Protein Similarity: 100 72.6 80.7 90.1 N.A. 97.4 96.7 N.A. 96.9 93.8 86.3 80 N.A. N.A. 62.2 N.A. N.A.
P-Site Identity: 100 13.3 100 13.3 N.A. 13.3 13.3 N.A. 6.6 6.6 0 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 33.3 100 20 N.A. 33.3 33.3 N.A. 13.3 20 33.3 26.6 N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 17 0 0 9 0 0 0 0 0 9 0 17 % A
% Cys: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 9 0 0 0 0 0 9 0 9 9 0 0 0 % D
% Glu: 0 25 0 0 0 9 9 42 9 34 0 9 0 17 0 % E
% Phe: 9 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 17 25 0 0 9 0 42 42 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 0 17 0 0 9 0 0 0 9 17 0 0 0 % I
% Lys: 0 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 0 0 0 0 0 0 0 0 0 9 0 17 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 42 0 0 9 9 0 17 0 9 0 9 % N
% Pro: 0 42 9 0 0 9 0 9 0 17 0 0 34 0 9 % P
% Gln: 0 9 42 0 0 0 9 0 0 0 0 0 0 25 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % R
% Ser: 17 9 25 34 0 50 25 17 59 42 17 9 17 42 34 % S
% Thr: 17 0 0 9 9 0 25 17 9 0 9 9 9 0 17 % T
% Val: 42 0 9 9 17 0 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 9 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _