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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6C
All Species:
15.76
Human Site:
T75
Identified Species:
26.67
UniProt:
P51160
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51160
NP_006195.3
858
99147
T75
T
V
Q
E
E
G
G
T
P
E
Q
G
V
H
R
Chimpanzee
Pan troglodytes
XP_001148438
858
99157
T75
T
V
Q
E
E
G
G
T
P
E
Q
G
V
H
R
Rhesus Macaque
Macaca mulatta
XP_001092604
858
99206
T75
T
V
Q
E
E
G
G
T
P
E
Q
G
V
H
R
Dog
Lupus familis
XP_543934
846
97567
A73
H
R
A
L
Q
K
L
A
Q
L
L
Q
A
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZQ1
861
98767
S75
C
M
Q
D
E
A
G
S
A
E
Q
M
A
H
R
Rat
Rattus norvegicus
Q8VID6
935
104553
P86
Q
G
S
A
N
S
H
P
A
S
G
G
G
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
A74
D
L
Q
E
N
L
Q
A
E
K
C
I
F
T
V
Chicken
Gallus gallus
P52731
862
99990
S75
E
I
Q
D
E
A
G
S
M
E
K
I
V
H
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957165
852
98238
M72
D
M
H
S
Q
P
V
M
E
K
A
M
H
K
V
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
R80
R
A
S
Q
K
E
L
R
K
T
F
A
R
S
K
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
S228
P
R
S
L
S
N
S
S
A
S
S
L
P
E
C
Honey Bee
Apis mellifera
XP_394107
1016
115998
I200
D
V
A
N
E
L
D
I
N
V
L
C
H
K
I
Nematode Worm
Caenorhab. elegans
P91119
710
81117
K32
E
I
S
P
E
T
F
K
R
W
A
V
R
R
T
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
L132
D
I
A
D
E
L
D
L
N
T
L
C
H
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.7
88.5
N.A.
86.5
23.8
N.A.
62.9
82.7
N.A.
69.4
24.2
23.7
25.3
22.9
33.3
Protein Similarity:
100
99.8
99.6
94
N.A.
93.9
45
N.A.
80
91.6
N.A.
82.5
43.1
40.3
44.1
41.3
53.6
P-Site Identity:
100
100
100
6.6
N.A.
46.6
6.6
N.A.
13.3
40
N.A.
0
0
0
13.3
6.6
6.6
P-Site Similarity:
100
100
100
13.3
N.A.
66.6
6.6
N.A.
26.6
73.3
N.A.
20
20
6.6
13.3
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
22
8
0
15
0
15
22
0
15
8
15
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
8
15
0
0
8
% C
% Asp:
29
0
0
22
0
0
15
0
0
0
0
0
0
8
0
% D
% Glu:
15
0
0
29
58
8
0
0
15
36
0
0
0
15
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
8
0
8
0
0
% F
% Gly:
0
8
0
0
0
22
36
0
0
0
8
29
8
0
0
% G
% His:
8
0
8
0
0
0
8
0
0
0
0
0
22
36
0
% H
% Ile:
0
22
0
0
0
0
0
8
0
0
0
15
0
0
15
% I
% Lys:
0
0
0
0
8
8
0
8
8
15
8
0
0
22
15
% K
% Leu:
0
8
0
15
0
22
15
8
0
8
22
8
0
0
0
% L
% Met:
0
15
0
0
0
0
0
8
8
0
0
15
0
0
0
% M
% Asn:
0
0
0
8
15
8
0
0
15
0
0
0
0
0
0
% N
% Pro:
8
0
0
8
0
8
0
8
22
0
0
0
8
0
0
% P
% Gln:
8
0
43
8
15
0
8
0
8
0
29
8
0
0
0
% Q
% Arg:
8
15
0
0
0
0
0
8
8
0
0
0
15
8
36
% R
% Ser:
0
0
29
8
8
8
8
22
0
15
8
0
0
8
8
% S
% Thr:
22
0
0
0
0
8
0
22
0
15
0
0
0
8
8
% T
% Val:
0
29
0
0
0
0
8
0
0
8
0
8
29
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _