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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6C
All Species:
38.79
Human Site:
Y174
Identified Species:
65.64
UniProt:
P51160
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51160
NP_006195.3
858
99147
Y174
F
M
D
K
Q
T
G
Y
V
T
K
N
L
L
A
Chimpanzee
Pan troglodytes
XP_001148438
858
99157
Y174
F
M
D
K
Q
T
G
Y
V
T
K
N
L
L
A
Rhesus Macaque
Macaca mulatta
XP_001092604
858
99206
Y174
F
M
D
K
Q
T
G
Y
V
T
K
N
L
L
A
Dog
Lupus familis
XP_543934
846
97567
Y159
F
M
D
K
Q
T
G
Y
V
T
K
N
L
M
A
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZQ1
861
98767
Y174
F
M
D
K
Q
T
G
Y
V
T
R
N
L
L
A
Rat
Rattus norvegicus
Q8VID6
935
104553
L221
N
D
L
D
L
T
S
L
S
Y
K
I
L
I
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
Y172
F
V
D
V
L
T
E
Y
E
T
K
N
I
L
A
Chicken
Gallus gallus
P52731
862
99990
Y174
Y
L
D
K
K
T
G
Y
T
T
V
N
M
M
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957165
852
98238
Y170
F
V
D
K
Q
T
G
Y
T
T
K
N
M
M
A
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
L179
N
D
L
D
L
T
S
L
S
Y
K
I
L
V
F
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
Y360
E
I
D
L
K
T
G
Y
K
T
N
A
I
L
C
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y299
S
I
D
M
R
T
G
Y
K
T
T
L
I
L
S
Nematode Worm
Caenorhab. elegans
P91119
710
81117
T111
G
A
F
S
C
R
K
T
E
N
G
E
L
K
L
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y230
E
V
D
K
I
T
G
Y
K
T
H
S
I
M
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.7
88.5
N.A.
86.5
23.8
N.A.
62.9
82.7
N.A.
69.4
24.2
23.7
25.3
22.9
33.3
Protein Similarity:
100
99.8
99.6
94
N.A.
93.9
45
N.A.
80
91.6
N.A.
82.5
43.1
40.3
44.1
41.3
53.6
P-Site Identity:
100
100
100
93.3
N.A.
93.3
20
N.A.
60
53.3
N.A.
73.3
20
40
40
6.6
40
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
73.3
86.6
N.A.
93.3
26.6
60
66.6
6.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
58
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
15
% C
% Asp:
0
15
79
15
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
15
0
0
0
0
0
8
0
15
0
0
8
0
0
0
% E
% Phe:
50
0
8
0
0
0
0
0
0
0
0
0
0
0
15
% F
% Gly:
8
0
0
0
0
0
72
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
15
0
0
8
0
0
0
0
0
0
15
29
8
0
% I
% Lys:
0
0
0
58
15
0
8
0
22
0
58
0
0
8
0
% K
% Leu:
0
8
15
8
22
0
0
15
0
0
0
8
58
50
8
% L
% Met:
0
36
0
8
0
0
0
0
0
0
0
0
15
29
0
% M
% Asn:
15
0
0
0
0
0
0
0
0
8
8
58
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
43
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
8
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
0
0
8
0
0
15
0
15
0
0
8
0
0
8
% S
% Thr:
0
0
0
0
0
93
0
8
15
79
8
0
0
0
0
% T
% Val:
0
22
0
8
0
0
0
0
36
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
79
0
15
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _