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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6C
All Species:
30.91
Human Site:
Y277
Identified Species:
52.31
UniProt:
P51160
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51160
NP_006195.3
858
99147
Y277
S
Y
L
N
C
E
R
Y
S
I
G
L
L
D
M
Chimpanzee
Pan troglodytes
XP_001148438
858
99157
Y277
T
Y
L
N
C
E
R
Y
S
I
G
L
L
D
M
Rhesus Macaque
Macaca mulatta
XP_001092604
858
99206
Y277
T
Y
L
N
C
E
R
Y
S
I
G
L
L
D
M
Dog
Lupus familis
XP_543934
846
97567
Y262
T
Y
L
N
C
E
R
Y
S
I
G
L
L
D
M
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZQ1
861
98767
Y277
T
Y
L
N
C
D
R
Y
S
I
G
L
L
D
M
Rat
Rattus norvegicus
Q8VID6
935
104553
A377
I
S
N
A
Q
L
F
A
A
S
R
K
E
Y
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
Y275
A
F
L
N
C
D
R
Y
S
V
G
L
L
D
M
Chicken
Gallus gallus
P52731
862
99990
Y277
M
Y
L
N
C
E
R
Y
S
V
G
L
L
D
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957165
852
98238
Y273
T
Y
L
Q
C
E
R
Y
S
C
G
L
L
D
M
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
A331
I
S
N
A
Q
L
F
A
A
S
R
K
E
Y
D
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
C465
E
L
L
K
C
E
R
C
S
V
F
L
V
D
L
Honey Bee
Apis mellifera
XP_394107
1016
115998
C404
E
L
L
K
C
E
R
C
A
V
Y
L
L
D
L
Nematode Worm
Caenorhab. elegans
P91119
710
81117
H208
G
S
D
G
Q
D
I
H
E
N
I
A
K
Q
R
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
C354
S
L
L
K
C
Q
R
C
M
V
F
I
L
E
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.7
88.5
N.A.
86.5
23.8
N.A.
62.9
82.7
N.A.
69.4
24.2
23.7
25.3
22.9
33.3
Protein Similarity:
100
99.8
99.6
94
N.A.
93.9
45
N.A.
80
91.6
N.A.
82.5
43.1
40.3
44.1
41.3
53.6
P-Site Identity:
100
93.3
93.3
93.3
N.A.
86.6
0
N.A.
73.3
86.6
N.A.
80
0
46.6
46.6
0
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
100
93.3
N.A.
86.6
6.6
66.6
66.6
13.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
15
0
0
0
15
22
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
79
0
0
22
0
8
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
22
0
0
0
0
0
0
0
72
8
% D
% Glu:
15
0
0
0
0
58
0
0
8
0
0
0
15
8
8
% E
% Phe:
0
8
0
0
0
0
15
0
0
0
15
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
0
0
0
0
58
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
0
0
0
8
0
0
36
8
8
0
0
0
% I
% Lys:
0
0
0
22
0
0
0
0
0
0
0
15
8
0
0
% K
% Leu:
0
22
79
0
0
15
0
0
0
0
0
72
72
0
15
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
58
% M
% Asn:
0
0
15
50
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
22
8
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
79
0
0
0
15
0
0
0
8
% R
% Ser:
15
22
0
0
0
0
0
0
65
15
0
0
0
0
0
% S
% Thr:
36
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
36
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
50
0
0
0
0
0
58
0
0
8
0
0
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _