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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6C
All Species:
29.39
Human Site:
Y507
Identified Species:
49.74
UniProt:
P51160
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51160
NP_006195.3
858
99147
Y507
D
P
R
S
A
E
L
Y
E
F
R
F
S
D
F
Chimpanzee
Pan troglodytes
XP_001148438
858
99157
Y507
D
P
R
S
A
E
L
Y
E
F
R
F
S
D
F
Rhesus Macaque
Macaca mulatta
XP_001092604
858
99206
Y507
D
P
R
S
A
E
L
Y
E
F
R
F
S
D
F
Dog
Lupus familis
XP_543934
846
97567
Y492
D
P
R
A
V
D
L
Y
E
F
R
F
S
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZQ1
861
98767
Y507
D
P
R
T
A
D
L
Y
E
F
C
F
S
D
F
Rat
Rattus norvegicus
Q8VID6
935
104553
D609
L
V
S
E
L
A
I
D
D
I
H
F
D
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
N504
D
P
E
Q
Y
E
I
N
Q
F
H
F
S
D
L
Chicken
Gallus gallus
P52731
862
99990
Y507
D
P
K
D
L
E
L
Y
E
F
R
F
S
D
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957165
852
98238
L502
E
A
K
D
V
D
L
L
E
F
S
F
S
D
F
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
D563
L
V
C
E
L
G
I
D
K
L
S
F
D
D
F
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
Y676
E
A
E
S
Y
N
L
Y
S
F
T
F
T
D
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y611
S
A
E
S
Y
N
L
Y
S
F
T
F
I
D
F
Nematode Worm
Caenorhab. elegans
P91119
710
81117
C410
V
L
A
Y
H
S
V
C
N
A
D
E
V
N
K
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y563
S
A
R
E
L
K
L
Y
E
F
S
F
S
D
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.7
88.5
N.A.
86.5
23.8
N.A.
62.9
82.7
N.A.
69.4
24.2
23.7
25.3
22.9
33.3
Protein Similarity:
100
99.8
99.6
94
N.A.
93.9
45
N.A.
80
91.6
N.A.
82.5
43.1
40.3
44.1
41.3
53.6
P-Site Identity:
100
100
100
80
N.A.
80
20
N.A.
46.6
80
N.A.
46.6
20
46.6
46.6
0
60
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
33.3
N.A.
60
86.6
N.A.
66.6
33.3
60
46.6
13.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
29
8
8
29
8
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
8
0
0
8
0
0
0
0
% C
% Asp:
50
0
0
15
0
22
0
15
8
0
8
0
15
93
0
% D
% Glu:
15
0
22
22
0
36
0
0
58
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
79
0
93
0
0
86
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
15
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
22
0
0
8
0
0
8
0
0
% I
% Lys:
0
0
15
0
0
8
0
0
8
0
0
0
0
0
8
% K
% Leu:
15
8
0
0
29
0
72
8
0
8
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
15
0
8
8
0
0
0
0
8
0
% N
% Pro:
0
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
43
0
0
0
0
0
0
0
36
0
0
0
0
% R
% Ser:
15
0
8
36
0
8
0
0
15
0
22
0
65
0
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
15
0
8
0
0
% T
% Val:
8
15
0
0
15
0
8
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
22
0
0
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _