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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCNN1D All Species: 7.58
Human Site: S599 Identified Species: 16.67
UniProt: P51172 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51172 NP_001123885.1 638 70215 S599 P P P A G G T S D D P E P S G
Chimpanzee Pan troglodytes O46547 638 70169 S599 P T P A G G T S D D P E P S G
Rhesus Macaque Macaca mulatta XP_001103409 726 81639 S680 H F C P H P T S L Y L S Q L G
Dog Lupus familis XP_546718 606 68405 N570 S R G A P E A N Q L P T D C R
Cat Felis silvestris
Mouse Mus musculus Q61180 699 78875 S650 R F C P H P T S P P P S L P Q
Rat Rattus norvegicus P37089 698 78869 S650 R F C P H P T S P P P S L P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514879 426 48716 E390 Y P L P R G A E Y C D Y N Q H
Chicken Gallus gallus Q92075 637 73218 G601 A F Q D E A S G L D A P H R F
Frog Xenopus laevis P51167 632 72609 Q584 I P R G D L S Q R Q I S V V A
Zebra Danio Brachydanio rerio Q708S3 558 62430 V522 A T V R F E E V K V K A A N D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09274 887 100314 S760 H K S S T T Q S V K L S V M D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 34.2 62.8 N.A. 34.4 34.9 N.A. 37.7 37.7 36.3 21.1 N.A. N.A. N.A. 22.2 N.A.
Protein Similarity: 100 99.2 51.3 71.4 N.A. 52.6 52.1 N.A. 45.9 56.5 56.4 36.8 N.A. N.A. N.A. 36.2 N.A.
P-Site Identity: 100 93.3 20 13.3 N.A. 20 20 N.A. 13.3 6.6 6.6 0 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 20 20 N.A. 20 20 N.A. 13.3 13.3 13.3 6.6 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 0 28 0 10 19 0 0 0 10 10 10 0 10 % A
% Cys: 0 0 28 0 0 0 0 0 0 10 0 0 0 10 0 % C
% Asp: 0 0 0 10 10 0 0 0 19 28 10 0 10 0 19 % D
% Glu: 0 0 0 0 10 19 10 10 0 0 0 19 0 0 0 % E
% Phe: 0 37 0 0 10 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 0 10 10 19 28 0 10 0 0 0 0 0 0 28 % G
% His: 19 0 0 0 28 0 0 0 0 0 0 0 10 0 10 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 0 10 10 10 0 0 0 0 % K
% Leu: 0 0 10 0 0 10 0 0 19 10 19 0 19 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 0 0 10 10 0 % N
% Pro: 19 28 19 37 10 28 0 0 19 19 46 10 19 19 0 % P
% Gln: 0 0 10 0 0 0 10 10 10 10 0 0 10 10 19 % Q
% Arg: 19 10 10 10 10 0 0 0 10 0 0 0 0 10 10 % R
% Ser: 10 0 10 10 0 0 19 55 0 0 0 46 0 19 0 % S
% Thr: 0 19 0 0 10 10 46 0 0 0 0 10 0 0 0 % T
% Val: 0 0 10 0 0 0 0 10 10 10 0 0 19 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 10 10 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _