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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCD1
All Species:
25.76
Human Site:
Y180
Identified Species:
47.22
UniProt:
P51178
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51178
NP_001124436.1
756
85665
Y180
N
I
Q
V
D
D
S
Y
A
R
K
I
F
R
E
Chimpanzee
Pan troglodytes
XP_001142960
788
88666
Y222
N
V
D
M
N
D
M
Y
A
Y
L
L
F
K
E
Rhesus Macaque
Macaca mulatta
XP_001089399
777
88189
Y201
N
I
Q
V
D
D
S
Y
A
R
K
I
F
R
E
Dog
Lupus familis
XP_859460
756
85972
Y180
N
I
Q
V
D
D
S
Y
A
R
K
I
F
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R3B1
756
85883
Y180
N
V
Q
V
D
D
S
Y
A
R
K
I
F
R
E
Rat
Rattus norvegicus
P10688
756
85944
Y180
N
I
Q
V
D
D
G
Y
A
R
K
I
F
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514368
738
83813
S173
I
F
K
E
C
D
K
S
N
T
D
S
L
E
D
Chicken
Gallus gallus
Q2VRL0
637
72514
E124
L
K
Y
E
P
I
D
E
V
R
K
R
R
Q
L
Frog
Xenopus laevis
Q32NH8
758
87399
H174
N
V
D
M
S
E
H
H
A
F
R
L
F
Q
M
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
Y199
N
I
D
L
N
E
Q
Y
A
R
T
L
F
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001008790
753
85559
N183
K
R
L
F
Q
F
A
N
T
H
S
T
T
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
D65
E
T
E
V
L
V
S
D
A
E
K
I
I
E
R
Baker's Yeast
Sacchar. cerevisiae
P32383
869
100529
I182
D
S
K
L
W
I
A
I
I
Y
K
V
S
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.3
95.3
93.9
N.A.
91
91.2
N.A.
66.4
38.7
51.3
47.1
N.A.
N.A.
N.A.
N.A.
41.9
Protein Similarity:
100
64.2
96
96.3
N.A.
94.5
94.4
N.A.
79.3
53.3
67.9
64.8
N.A.
N.A.
N.A.
N.A.
63.2
P-Site Identity:
100
40
100
100
N.A.
93.3
93.3
N.A.
6.6
13.3
20
40
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
73.3
100
100
N.A.
100
93.3
N.A.
20
20
66.6
80
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
24.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
16
0
70
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
24
0
39
54
8
8
0
0
8
0
0
0
8
% D
% Glu:
8
0
8
16
0
16
0
8
0
8
0
0
0
16
47
% E
% Phe:
0
8
0
8
0
8
0
0
0
8
0
0
62
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
8
0
8
0
0
0
0
0
% H
% Ile:
8
39
0
0
0
16
0
8
8
0
0
47
8
0
0
% I
% Lys:
8
8
16
0
0
0
8
0
0
0
62
0
0
16
24
% K
% Leu:
8
0
8
16
8
0
0
0
0
0
8
24
8
0
8
% L
% Met:
0
0
0
16
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
62
0
0
0
16
0
0
8
8
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
39
0
8
0
8
0
0
0
0
0
0
16
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
54
8
8
8
39
8
% R
% Ser:
0
8
0
0
8
0
39
8
0
0
8
8
8
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
8
8
8
8
8
8
0
% T
% Val:
0
24
0
47
0
8
0
0
8
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
54
0
16
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _