Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 25.15
Human Site: S133 Identified Species: 39.52
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 S133 S G T S I A S S I R C M R R A
Chimpanzee Pan troglodytes XP_001163213 1147 129515 S220 S G T S I A S S I R C M R R A
Rhesus Macaque Macaca mulatta XP_001083328 329 36913
Dog Lupus familis XP_546133 1046 118517 S132 S G T S I A S S I R C M R R A
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 S134 S G T S V A S S I R C L R R A
Rat Rattus norvegicus XP_241671 1060 119682 S134 S G T S V A S S I R C L R R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551
Chicken Gallus gallus Q5ZKG3 992 111650 S123 F R G S E C G S R Q T L V G T
Frog Xenopus laevis Q8QHA5 1053 119713 G139 S G T S I A N G I R C L R R S
Zebra Danio Brachydanio rerio XP_687974 1397 155209 M454 I A S S I R C M R R G V L G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 S160 S G T T V T G S L F C K R K S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 S113 M D E V E E Y S L K V D E D N
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 C194 A D L S G A Q C P Y K V L R L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 S179 S S P S K K A S K R P A F A T
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 P242 P S S P I K A P N V E K K A E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 0 100 N.A. 86.6 86.6 N.A. 0 13.3 73.3 20 N.A. 40 N.A. N.A. 6.6
P-Site Similarity: 100 100 0 100 N.A. 100 100 N.A. 0 26.6 93.3 33.3 N.A. 73.3 N.A. N.A. 20
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 20 N.A. N.A. 26.6 6.6 N.A.
P-Site Similarity: 33.3 N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 0 47 14 0 0 0 0 7 0 14 34 % A
% Cys: 0 0 0 0 0 7 7 7 0 0 47 0 0 0 0 % C
% Asp: 0 14 0 0 0 0 0 0 0 0 0 7 0 7 0 % D
% Glu: 0 0 7 0 14 7 0 0 0 0 7 0 7 0 14 % E
% Phe: 7 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % F
% Gly: 0 47 7 0 7 0 14 7 0 0 7 0 0 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 40 0 0 0 40 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 7 14 0 0 7 7 7 14 7 7 0 % K
% Leu: 0 0 7 0 0 0 0 0 14 0 0 27 14 0 7 % L
% Met: 7 0 0 0 0 0 0 7 0 0 0 20 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 7 0 0 0 0 0 7 % N
% Pro: 7 0 7 7 0 0 0 7 7 0 7 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 7 0 0 14 54 0 0 47 47 0 % R
% Ser: 54 14 14 67 0 0 34 60 0 0 0 0 0 0 14 % S
% Thr: 0 0 47 7 0 7 0 0 0 0 7 0 0 0 14 % T
% Val: 0 0 0 7 20 0 0 0 0 7 7 14 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _