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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 21.21
Human Site: S321 Identified Species: 33.33
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 S321 V V L Y T L L S Q E R R A D P
Chimpanzee Pan troglodytes XP_001163213 1147 129515 S408 V V L Y T L L S Q E R R A D P
Rhesus Macaque Macaca mulatta XP_001083328 329 36913
Dog Lupus familis XP_546133 1046 118517 S320 L V L Y T L L S Q E R R A D P
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 S322 V V L Y T L L S Q E R R E D P
Rat Rattus norvegicus XP_241671 1060 119682 S322 V I L Y T L L S Q E R R E D P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551
Chicken Gallus gallus Q5ZKG3 992 111650 P311 L K T G T M Y P V T G T R M D
Frog Xenopus laevis Q8QHA5 1053 119713 E327 L L S Q E R R E D P E A G L L
Zebra Danio Brachydanio rerio XP_687974 1397 155209 S642 V I L Y T L M S S A R R C D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 L348 Q S G L L L Y L K E G L L R E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 K301 A D W P S Q T K P S L I P P I
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 D382 L S I S E V I D I E E M A W A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 N367 V S P G D S I N V I G E F D G
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 V430 V I V S L R S V E L P K I G T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 0 93.3 N.A. 93.3 86.6 N.A. 0 6.6 0 66.6 N.A. 13.3 N.A. N.A. 0
P-Site Similarity: 100 100 0 100 N.A. 93.3 93.3 N.A. 0 20 13.3 80 N.A. 20 N.A. N.A. 6.6
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 13.3 N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: 40 N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 0 0 7 0 7 27 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 7 0 0 7 0 0 7 7 0 0 0 0 47 7 % D
% Glu: 0 0 0 0 14 0 0 7 7 47 14 7 14 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 0 7 14 0 0 0 0 0 0 20 0 7 7 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 20 7 0 0 0 14 0 7 7 0 7 7 0 7 % I
% Lys: 0 7 0 0 0 0 0 7 7 0 0 7 0 0 0 % K
% Leu: 27 7 40 7 14 47 34 7 0 7 7 7 7 7 7 % L
% Met: 0 0 0 0 0 7 7 0 0 0 0 7 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 7 7 0 0 0 7 7 7 7 0 7 7 40 % P
% Gln: 7 0 0 7 0 7 0 0 34 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 14 7 0 0 0 40 40 7 7 0 % R
% Ser: 0 20 7 14 7 7 7 40 7 7 0 0 0 0 0 % S
% Thr: 0 0 7 0 47 0 7 0 0 7 0 7 0 0 7 % T
% Val: 47 27 7 0 0 7 0 7 14 0 0 0 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 40 0 0 14 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _