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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 26.36
Human Site: S531 Identified Species: 41.43
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 S531 E R S L F A L S R G Y V K E I
Chimpanzee Pan troglodytes XP_001163213 1147 129515 S618 E R S L F A L S R G Y V K E I
Rhesus Macaque Macaca mulatta XP_001083328 329 36913
Dog Lupus familis XP_546133 1046 118517 S531 E R T L F A L S R G Y V K E I
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 S532 E R K L F A L S K G Y V K K M
Rat Rattus norvegicus XP_241671 1060 119682 S531 E R K L F A L S K G Y V K R I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551 S125 L S K L M E N S P A S E K L R
Chicken Gallus gallus Q5ZKG3 992 111650 A509 G Y V R E I S A T K I S C L L
Frog Xenopus laevis Q8QHA5 1053 119713 S532 E E R F L A L S T G Y I K E V
Zebra Danio Brachydanio rerio XP_687974 1397 155209 S849 D S V L I G L S T G Y V T E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 A546 S T S R L A V A A G F I V S I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 S499 Y R I D K D D S Y N S M A A S
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 S634 S G D Y V I I S T K F G R Q T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 L644 T Q Q L P P M L R A D G G N T
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 C911 E E G H F C L C Q G R V Q F I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 0 93.3 N.A. 73.3 80 N.A. 20 0 53.3 53.3 N.A. 26.6 N.A. N.A. 13.3
P-Site Similarity: 100 100 0 100 N.A. 93.3 86.6 N.A. 20 13.3 66.6 60 N.A. 53.3 N.A. N.A. 20
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 40 N.A.
P-Site Similarity: 33.3 N.A. N.A. 26.6 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 47 0 14 7 14 0 0 7 7 0 % A
% Cys: 0 0 0 0 0 7 0 7 0 0 0 0 7 0 0 % C
% Asp: 7 0 7 7 0 7 7 0 0 0 7 0 0 0 0 % D
% Glu: 47 14 0 0 7 7 0 0 0 0 0 7 0 34 0 % E
% Phe: 0 0 0 7 40 0 0 0 0 0 14 0 0 7 0 % F
% Gly: 7 7 7 0 0 7 0 0 0 60 0 14 7 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 7 14 7 0 0 0 7 14 0 0 47 % I
% Lys: 0 0 20 0 7 0 0 0 14 14 0 0 47 7 0 % K
% Leu: 7 0 0 54 14 0 54 7 0 0 0 0 0 14 7 % L
% Met: 0 0 0 0 7 0 7 0 0 0 0 7 0 0 7 % M
% Asn: 0 0 0 0 0 0 7 0 0 7 0 0 0 7 0 % N
% Pro: 0 0 0 0 7 7 0 0 7 0 0 0 0 0 0 % P
% Gln: 0 7 7 0 0 0 0 0 7 0 0 0 7 7 0 % Q
% Arg: 0 40 7 14 0 0 0 0 27 0 7 0 7 7 7 % R
% Ser: 14 14 20 0 0 0 7 67 0 0 14 7 0 7 7 % S
% Thr: 7 7 7 0 0 0 0 0 27 0 0 0 7 0 14 % T
% Val: 0 0 14 0 7 0 7 0 0 0 0 47 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 7 0 0 0 0 7 0 47 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _