Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 10.3
Human Site: S975 Identified Species: 16.19
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 S975 K Y Q G R D K S I V L V S F V
Chimpanzee Pan troglodytes XP_001163213 1147 129515 S1062 K Y Q G R D K S I V L V S F V
Rhesus Macaque Macaca mulatta XP_001083328 329 36913 D249 V D K Y Q G R D K S I V L V S
Dog Lupus familis XP_546133 1046 118517 V964 S S I R M V E V N T V D K Y Q
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 K976 D K Y Q G R D K S L I L V S F
Rat Rattus norvegicus XP_241671 1060 119682 K973 D K Y Q G R D K S L I L V S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551 I517 Y Q G R D K S I I L V S F V R
Chicken Gallus gallus Q5ZKG3 992 111650 S911 K Y Q G R D K S I I I V S F V
Frog Xenopus laevis Q8QHA5 1053 119713 V964 L S A S A V E V N T V D K Y Q
Zebra Danio Brachydanio rerio XP_687974 1397 155209 K1293 D K Y Q G R D K S V I I V S F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 N1006 Q F Q G R D K N L I I Y S C S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 N891 K V K S L E V N T V D K Y Q G
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 T1068 V T S V E I H T I D K Y Q G R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 T1210 T T P V E I H T I D K Y Q G R
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 K1399 D Q F Q G R D K K C I I I S M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 6.6 0 N.A. 0 0 N.A. 6.6 86.6 0 6.6 N.A. 40 N.A. N.A. 13.3
P-Site Similarity: 100 100 33.3 20 N.A. 20 20 N.A. 20 100 20 20 N.A. 80 N.A. N.A. 33.3
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % C
% Asp: 27 7 0 0 7 27 27 7 0 14 7 14 0 0 0 % D
% Glu: 0 0 0 0 14 7 14 0 0 0 0 0 0 0 0 % E
% Phe: 0 7 7 0 0 0 0 0 0 0 0 0 7 20 20 % F
% Gly: 0 0 7 27 27 7 0 0 0 0 0 0 0 14 7 % G
% His: 0 0 0 0 0 0 14 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 14 0 7 40 14 47 14 7 0 0 % I
% Lys: 27 20 14 0 0 7 27 27 14 0 14 7 14 0 0 % K
% Leu: 7 0 0 0 7 0 0 0 7 20 14 14 7 0 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 14 14 0 0 0 0 0 0 % N
% Pro: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 14 27 27 7 0 0 0 0 0 0 0 14 7 14 % Q
% Arg: 0 0 0 14 27 27 7 0 0 0 0 0 0 0 20 % R
% Ser: 7 14 7 14 0 0 7 20 20 7 0 7 27 27 14 % S
% Thr: 7 14 0 0 0 0 0 14 7 14 0 0 0 0 0 % T
% Val: 14 7 0 14 0 14 7 14 0 27 20 27 20 14 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 20 20 7 0 0 0 0 0 0 0 20 7 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _