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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 6.67
Human Site: T989 Identified Species: 10.48
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 T989 V R S N K D G T V G E L L K D
Chimpanzee Pan troglodytes XP_001163213 1147 129515 T1076 V R S N K D G T V G E L L K D
Rhesus Macaque Macaca mulatta XP_001083328 329 36913 D263 S F V R S N K D G T V G E L L
Dog Lupus familis XP_546133 1046 118517 I978 Q G R D K S I I L V S F V R S
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 G990 F V R S N E D G T L G E L L K
Rat Rattus norvegicus XP_241671 1060 119682 G987 F V R S N E D G T L G E L L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551 L531 R N N K D G T L G D L L K D W
Chicken Gallus gallus Q5ZKG3 992 111650 N925 V R N S N D E N L G A L L E D
Frog Xenopus laevis Q8QHA5 1053 119713 I978 Q G R D K S V I I V S F V R S
Zebra Danio Brachydanio rerio XP_687974 1397 155209 G1307 F V R S N A E G N L G E L L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 S1020 S K T G G D F S D M E R S R E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 V905 G R D K D V I V M S F S H S Q
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 V1082 R D K E C I L V S F A R S S E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 V1224 R D K D C I L V S F V R S R E
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 L1413 M V R R N S Q L N G G A L L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 0 6.6 N.A. 6.6 6.6 N.A. 6.6 46.6 6.6 6.6 N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 100 6.6 33.3 N.A. 20 20 N.A. 13.3 73.3 33.3 13.3 N.A. 46.6 N.A. N.A. 13.3
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 0 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 0 0 0 14 7 0 0 0 % A
% Cys: 0 0 0 0 14 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 14 7 20 14 27 14 7 7 7 0 0 0 7 20 % D
% Glu: 0 0 0 7 0 14 14 0 0 0 20 20 7 7 20 % E
% Phe: 20 7 0 0 0 0 7 0 0 14 7 14 0 0 0 % F
% Gly: 7 14 0 7 7 7 14 20 14 27 27 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 0 0 0 0 0 14 14 14 7 0 0 0 0 0 0 % I
% Lys: 0 7 14 14 27 0 7 0 0 0 0 0 7 14 20 % K
% Leu: 0 0 0 0 0 0 14 14 14 20 7 27 47 34 7 % L
% Met: 7 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % M
% Asn: 0 7 14 14 34 7 0 7 14 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 14 0 0 0 0 0 7 0 0 0 0 0 0 0 14 % Q
% Arg: 20 27 40 14 0 0 0 0 0 0 0 20 0 27 0 % R
% Ser: 14 0 14 27 7 20 0 7 14 7 14 7 20 14 14 % S
% Thr: 0 0 7 0 0 0 7 14 14 7 0 0 0 0 0 % T
% Val: 20 27 7 0 0 7 7 20 14 14 14 0 14 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _