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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNA2 All Species: 14.24
Human Site: Y873 Identified Species: 22.38
UniProt: P51530 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51530 NP_001073918 1060 120415 Y873 V K L E L E F Y A D Y S D N P
Chimpanzee Pan troglodytes XP_001163213 1147 129515 Y960 V K L E L E F Y A D Y S D N P
Rhesus Macaque Macaca mulatta XP_001083328 329 36913 S152 L E F Y A D Y S D N P W L M G
Dog Lupus familis XP_546133 1046 118517 V866 N L P N L K D V K L E L E F Y
Cat Felis silvestris
Mouse Mus musculus Q6ZQJ5 1062 119429 Y874 A R L S L Q L Y A D Y S D S P
Rat Rattus norvegicus XP_241671 1060 119682 Y871 K D V R L E F Y A D Y S D N P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520571 597 66551 L420 Y A D Y S E T L W L K G V F E
Chicken Gallus gallus Q5ZKG3 992 111650 K814 N K L V Y E G K L E C G S E K
Frog Xenopus laevis Q8QHA5 1053 119713 T866 V Q L P H I K T L L L E L E F
Zebra Danio Brachydanio rerio XP_687974 1397 155209 Q1182 L Q L P S R A Q A E E E L E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727386 1100 124571 H885 V Q R A L T T H L E Q A V T L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790939 971 108124 D794 T V S L P N W D A W C K E S C
Poplar Tree Populus trichocarpa XP_002321254 1152 128362 I970 L R C G S S E I A N A R L K F
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172361 1296 143231 V1112 L C C G S A E V A D A T L V L
Baker's Yeast Sacchar. cerevisiae P38859 1522 171676 R1295 P E A L S R Y R N E S A N S K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92 29 84.1 N.A. 79.8 79.7 N.A. 44.7 62.2 62.5 45.2 N.A. 32.4 N.A. N.A. 37.2
Protein Similarity: 100 92.1 29.8 90.1 N.A. 89.1 88.8 N.A. 50.7 76.5 77.5 58 N.A. 53.2 N.A. N.A. 55.8
P-Site Identity: 100 100 0 6.6 N.A. 60 73.3 N.A. 6.6 20 13.3 13.3 N.A. 13.3 N.A. N.A. 6.6
P-Site Similarity: 100 100 33.3 20 N.A. 80 80 N.A. 6.6 26.6 20 33.3 N.A. 40 N.A. N.A. 26.6
Percent
Protein Identity: 27 N.A. N.A. 27.5 24.8 N.A.
Protein Similarity: 44.7 N.A. N.A. 43.8 41.5 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 7 7 7 7 0 54 0 14 14 0 0 0 % A
% Cys: 0 7 14 0 0 0 0 0 0 0 14 0 0 0 7 % C
% Asp: 0 7 7 0 0 7 7 7 7 34 0 0 27 0 0 % D
% Glu: 0 14 0 14 0 34 14 0 0 27 14 14 14 20 7 % E
% Phe: 0 0 7 0 0 0 20 0 0 0 0 0 0 14 14 % F
% Gly: 0 0 0 14 0 0 7 0 0 0 0 14 0 0 7 % G
% His: 0 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 0 % I
% Lys: 7 20 0 0 0 7 7 7 7 0 7 7 0 7 14 % K
% Leu: 27 7 40 14 40 0 7 7 20 20 7 7 34 0 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 14 0 0 7 0 7 0 0 7 14 0 0 7 20 0 % N
% Pro: 7 0 7 14 7 0 0 0 0 0 7 0 0 0 27 % P
% Gln: 0 20 0 0 0 7 0 7 0 0 7 0 0 0 0 % Q
% Arg: 0 14 7 7 0 14 0 7 0 0 0 7 0 0 0 % R
% Ser: 0 0 7 7 34 7 0 7 0 0 7 27 7 20 0 % S
% Thr: 7 0 0 0 0 7 14 7 0 0 0 7 0 7 0 % T
% Val: 27 7 7 7 0 0 0 14 0 0 0 0 14 7 0 % V
% Trp: 0 0 0 0 0 0 7 0 7 7 0 7 0 0 0 % W
% Tyr: 7 0 0 14 7 0 14 27 0 0 27 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _