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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDH3G All Species: 10
Human Site: S48 Identified Species: 20
UniProt: P51553 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51553 NP_004126.1 393 42794 S48 S E Q T I P P S A K Y G G R H
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P70404 393 42767 S48 S Q Q T I P P S A K Y G G R H
Rat Rattus norvegicus P41565 393 42833 S48 S Q Q T I P P S A K Y G G R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511168 376 41276 M42 G G R H T V T M I P G D G I G
Chicken Gallus gallus
Frog Xenopus laevis NP_001086122 391 42851 P45 R D Y S I P P P A K Y G G R H
Zebra Danio Brachydanio rerio XP_699839 289 31870
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VWH4 377 40826 R41 N A T P A A S R S Y S S G T K
Honey Bee Apis mellifera XP_393876 384 42391 K45 K K V M P I P K A H Y G G R H
Nematode Worm Caenorhab. elegans Q93353 379 41534 L39 A P R P P T E L N Q K L K V T
Sea Urchin Strong. purpuratus XP_001175786 362 39467 H46 H L R E V F R H A H V P V D F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q945K7 374 40606 S39 S V A R A F C S S T T P I T A
Baker's Yeast Sacchar. cerevisiae P28834 360 39306 V39 T L I P G D G V G K E I T D S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 95.1 95.6 N.A. 88.8 N.A. 77.8 56.7 N.A. 40.9 53.6 47.5 60
Protein Similarity: 100 N.A. N.A. N.A. N.A. 97.1 97.9 N.A. 92.3 N.A. 85.7 64.6 N.A. 60.3 68.9 65.3 73.7
P-Site Identity: 100 N.A. N.A. N.A. N.A. 93.3 93.3 N.A. 6.6 N.A. 66.6 0 N.A. 6.6 46.6 0 6.6
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. 13.3 N.A. 80 0 N.A. 20 53.3 20 20
Percent
Protein Identity: N.A. N.A. N.A. 44 45.2 N.A.
Protein Similarity: N.A. N.A. N.A. 60.8 63.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 9 0 17 9 0 0 50 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 9 0 0 0 0 0 9 0 17 0 % D
% Glu: 0 9 0 9 0 0 9 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 9 % F
% Gly: 9 9 0 0 9 0 9 0 9 0 9 42 59 0 9 % G
% His: 9 0 0 9 0 0 0 9 0 17 0 0 0 0 42 % H
% Ile: 0 0 9 0 34 9 0 0 9 0 0 9 9 9 0 % I
% Lys: 9 9 0 0 0 0 0 9 0 42 9 0 9 0 9 % K
% Leu: 0 17 0 0 0 0 0 9 0 0 0 9 0 0 0 % L
% Met: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % N
% Pro: 0 9 0 25 17 34 42 9 0 9 0 17 0 0 0 % P
% Gln: 0 17 25 0 0 0 0 0 0 9 0 0 0 0 0 % Q
% Arg: 9 0 25 9 0 0 9 9 0 0 0 0 0 42 0 % R
% Ser: 34 0 0 9 0 0 9 34 17 0 9 9 0 0 9 % S
% Thr: 9 0 9 25 9 9 9 0 0 9 9 0 9 17 9 % T
% Val: 0 9 9 0 9 9 0 9 0 0 9 0 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 9 42 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _