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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
21.52
Human Site:
S108
Identified Species:
52.59
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
S108
T
E
Q
N
L
S
Y
S
E
E
P
I
T
E
I
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
S108
T
E
Q
N
L
S
Y
S
E
E
P
I
T
E
I
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
T108
T
E
Q
N
L
S
Y
T
E
E
P
I
T
E
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
T103
A
E
Q
N
L
S
Y
T
E
E
P
L
A
E
I
Rat
Rattus norvegicus
Q9Z0T0
240
27673
T103
A
E
Q
N
L
S
Y
T
E
E
P
L
T
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
T209
T
D
Q
N
L
S
Y
T
E
K
P
V
G
E
I
Chicken
Gallus gallus
XP_418921
239
26809
C101
A
D
Q
N
L
P
Y
C
E
E
P
V
P
G
I
Frog
Xenopus laevis
NP_001087908
243
27600
V106
D
E
Q
N
I
P
Y
V
E
E
T
V
P
E
I
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
A98
E
Y
N
E
E
A
V
A
D
I
P
G
A
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
D111
K
I
K
I
Y
L
C
D
F
F
Q
F
S
K
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
93.3
N.A.
N.A.
73.3
80
N.A.
66.6
53.3
53.3
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
93.3
N.A.
93.3
66.6
66.6
40
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
0
0
0
0
10
0
10
0
0
0
0
20
0
0
% A
% Cys:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% C
% Asp:
10
20
0
0
0
0
0
10
10
0
0
0
0
0
10
% D
% Glu:
10
60
0
10
10
0
0
0
80
70
0
0
0
70
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
10
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
10
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
10
10
0
0
0
0
10
0
30
0
0
80
% I
% Lys:
10
0
10
0
0
0
0
0
0
10
0
0
0
20
0
% K
% Leu:
0
0
0
0
70
10
0
0
0
0
0
20
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
80
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
20
0
0
0
0
80
0
20
0
0
% P
% Gln:
0
0
80
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
60
0
20
0
0
0
0
10
0
0
% S
% Thr:
40
0
0
0
0
0
0
40
0
0
10
0
40
0
0
% T
% Val:
0
0
0
0
0
0
10
10
0
0
0
30
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
10
0
80
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _