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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
24.55
Human Site:
S125
Identified Species:
60
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
S125
T
K
V
F
K
S
S
S
G
N
I
S
L
Y
C
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
S125
T
K
V
F
K
S
S
S
G
N
I
S
L
Y
C
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
S125
A
K
V
F
K
S
S
S
G
N
I
S
L
Y
C
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
S120
A
K
V
F
K
S
S
S
G
S
I
S
L
Y
C
Rat
Rattus norvegicus
Q9Z0T0
240
27673
S120
A
K
V
F
K
S
S
S
G
N
I
S
L
Y
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
S226
A
K
V
F
Q
S
T
S
L
N
I
S
L
F
C
Chicken
Gallus gallus
XP_418921
239
26809
S118
A
K
K
L
Q
S
T
S
G
N
I
C
L
Y
C
Frog
Xenopus laevis
NP_001087908
243
27600
I123
A
K
S
S
T
G
N
I
S
L
Y
C
C
N
M
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
I115
S
T
D
G
K
I
S
I
Y
Q
C
D
L
Y
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
D128
G
Q
F
D
A
I
W
D
R
G
A
L
V
A
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
93.3
N.A.
N.A.
86.6
93.3
N.A.
66.6
60
6.6
26.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
N.A.
N.A.
93.3
93.3
N.A.
86.6
73.3
13.3
33.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
0
0
0
10
0
0
0
0
0
10
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
20
10
0
70
% C
% Asp:
0
0
10
10
0
0
0
10
0
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
60
0
0
0
0
0
0
0
0
0
10
0
% F
% Gly:
10
0
0
10
0
10
0
0
60
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
20
0
20
0
0
70
0
0
0
10
% I
% Lys:
0
80
10
0
60
0
0
0
0
0
0
0
0
0
10
% K
% Leu:
0
0
0
10
0
0
0
0
10
10
0
10
80
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
10
0
0
60
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
20
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% R
% Ser:
10
0
10
10
0
70
60
70
10
10
0
60
0
0
0
% S
% Thr:
20
10
0
0
10
0
20
0
0
0
0
0
0
0
0
% T
% Val:
0
0
60
0
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
10
0
0
70
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _