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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
8.79
Human Site:
S61
Identified Species:
21.48
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
S61
D
T
F
L
K
G
K
S
G
L
R
V
F
F
P
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
S61
D
T
F
L
K
G
K
S
G
L
R
V
F
F
P
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
S61
D
T
F
L
K
D
K
S
G
L
R
V
F
F
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
C65
L
R
V
F
F
P
L
C
G
K
A
I
E
M
K
Rat
Rattus norvegicus
Q9Z0T0
240
27673
F62
Q
S
G
L
R
V
F
F
P
L
C
G
K
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
N162
N
T
L
L
N
D
K
N
G
L
R
I
F
F
P
Chicken
Gallus gallus
XP_418921
239
26809
F60
R
S
G
L
R
I
F
F
P
L
C
G
K
A
V
Frog
Xenopus laevis
NP_001087908
243
27600
A59
E
E
M
V
N
T
R
A
Q
I
R
I
F
F
P
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
D60
P
L
C
G
K
A
V
D
M
K
W
L
A
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
L70
V
V
G
V
E
G
V
L
Q
A
V
M
E
F
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
93.3
N.A.
N.A.
6.6
13.3
N.A.
60
13.3
26.6
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
N.A.
N.A.
13.3
26.6
N.A.
80
26.6
66.6
13.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
0
10
10
0
10
20
0
% A
% Cys:
0
0
10
0
0
0
0
10
0
0
20
0
0
0
0
% C
% Asp:
30
0
0
0
0
20
0
10
0
0
0
0
0
10
0
% D
% Glu:
10
10
0
0
10
0
0
0
0
0
0
0
20
0
0
% E
% Phe:
0
0
30
10
10
0
20
20
0
0
0
0
50
60
10
% F
% Gly:
0
0
30
10
0
30
0
0
50
0
0
20
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
10
0
30
0
0
10
% I
% Lys:
0
0
0
0
40
0
40
0
0
20
0
0
20
0
10
% K
% Leu:
10
10
10
60
0
0
10
10
0
60
0
10
0
0
0
% L
% Met:
0
0
10
0
0
0
0
0
10
0
0
10
0
10
10
% M
% Asn:
10
0
0
0
20
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
10
0
0
20
0
0
0
0
0
50
% P
% Gln:
10
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% Q
% Arg:
10
10
0
0
20
0
10
0
0
0
50
0
0
0
0
% R
% Ser:
0
20
0
0
0
0
0
30
0
0
0
0
0
0
0
% S
% Thr:
0
40
0
0
0
10
0
0
0
0
0
0
0
0
0
% T
% Val:
10
10
10
20
0
10
20
0
0
0
10
30
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _