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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
13.94
Human Site:
T141
Identified Species:
34.07
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
T141
S
I
F
D
L
P
R
T
N
I
G
K
F
D
M
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
T141
S
I
F
D
L
P
R
T
N
I
G
K
F
D
M
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
T141
S
I
F
D
F
P
R
T
N
I
G
K
F
D
M
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
A136
S
I
F
D
L
P
R
A
N
I
G
K
F
D
R
Rat
Rattus norvegicus
Q9Z0T0
240
27673
A136
S
I
F
D
L
P
R
A
N
I
G
K
F
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
T242
S
I
F
D
F
P
R
T
N
V
G
K
F
D
G
Chicken
Gallus gallus
XP_418921
239
26809
A134
S
I
Y
D
L
S
S
A
L
V
G
K
F
D
G
Frog
Xenopus laevis
NP_001087908
243
27600
G139
D
L
S
S
S
I
I
G
K
F
G
G
I
W
D
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
F131
S
S
A
V
A
G
H
F
G
G
I
W
D
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
T144
P
S
L
R
K
Q
Y
T
D
V
L
L
S
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
93.3
N.A.
N.A.
86.6
86.6
N.A.
80
53.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
N.A.
N.A.
86.6
86.6
N.A.
86.6
66.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
0
0
30
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
70
0
0
0
0
10
0
0
0
10
70
10
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
60
0
20
0
0
10
0
10
0
0
70
0
0
% F
% Gly:
0
0
0
0
0
10
0
10
10
10
80
10
0
0
30
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
70
0
0
0
10
10
0
0
50
10
0
10
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
10
0
0
70
0
0
0
% K
% Leu:
0
10
10
0
50
0
0
0
10
0
10
10
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
30
% M
% Asn:
0
0
0
0
0
0
0
0
60
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
60
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
60
0
0
0
0
0
0
10
20
% R
% Ser:
80
20
10
10
10
10
10
0
0
0
0
0
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
0
30
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% W
% Tyr:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _