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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
8.18
Human Site:
T169
Identified Species:
20
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
T169
D
R
K
C
Y
A
D
T
M
F
S
L
L
G
K
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
T169
D
R
K
C
Y
A
D
T
M
L
S
L
L
G
K
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
T169
D
R
K
R
Y
A
D
T
M
L
S
L
L
G
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
I164
D
H
D
R
Y
A
D
I
I
L
S
L
L
R
K
Rat
Rattus norvegicus
Q9Z0T0
240
27673
I164
D
R
D
R
Y
A
D
I
I
L
S
L
L
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
L270
D
R
E
R
Y
A
N
L
M
L
P
L
M
D
A
Chicken
Gallus gallus
XP_418921
239
26809
L162
D
R
Q
R
Y
V
T
L
M
S
S
L
M
E
K
Frog
Xenopus laevis
NP_001087908
243
27600
L164
D
R
E
R
Y
T
K
L
I
L
T
L
M
E
N
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
L154
D
R
Q
K
Y
A
S
L
L
V
S
L
M
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
F162
G
R
I
L
N
E
V
F
E
Y
N
P
E
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
93.3
86.6
N.A.
N.A.
53.3
60
N.A.
40
46.6
26.6
40
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
86.6
N.A.
N.A.
60
66.6
N.A.
60
60
53.3
60
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
70
0
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
90
0
20
0
0
0
50
0
0
0
0
0
0
10
0
% D
% Glu:
0
0
20
0
0
10
0
0
10
0
0
0
10
30
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
0
0
0
30
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
20
30
0
0
0
0
0
0
% I
% Lys:
0
0
30
10
0
0
10
0
0
0
0
0
0
0
60
% K
% Leu:
0
0
0
10
0
0
0
40
10
60
0
90
50
0
0
% L
% Met:
0
0
0
0
0
0
0
0
50
0
0
0
40
0
0
% M
% Asn:
0
0
0
0
10
0
10
0
0
0
10
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% P
% Gln:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
90
0
60
0
0
0
0
0
0
0
0
0
20
10
% R
% Ser:
0
0
0
0
0
0
10
0
0
10
70
0
0
10
10
% S
% Thr:
0
0
0
0
0
10
10
30
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
10
10
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
90
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _