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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
26.67
Human Site:
Y198
Identified Species:
65.19
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
Y198
K
H
P
G
P
P
F
Y
V
P
H
A
E
I
E
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
Y198
K
H
P
G
P
P
F
Y
V
P
H
A
E
I
E
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
Y198
K
H
P
G
P
P
F
Y
V
P
H
A
E
I
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
Y193
K
H
A
G
P
P
F
Y
V
P
S
A
E
L
K
Rat
Rattus norvegicus
Q9Z0T0
240
27673
Y193
K
H
T
G
P
P
F
Y
V
P
D
A
E
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
Y299
R
H
G
G
P
P
F
Y
V
S
D
S
E
V
Q
Chicken
Gallus gallus
XP_418921
239
26809
Y191
K
H
N
G
P
P
F
Y
V
P
E
S
E
V
K
Frog
Xenopus laevis
NP_001087908
243
27600
Y193
L
V
Q
G
P
P
F
Y
I
S
D
T
V
R
E
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
F183
L
Y
K
G
P
P
F
F
V
S
E
D
D
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
F191
Q
K
F
F
G
E
K
F
T
I
E
V
L
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
100
N.A.
N.A.
73.3
73.3
N.A.
53.3
66.6
40
40
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
86.6
N.A.
80
86.6
46.6
66.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
50
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
30
10
10
0
10
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
30
0
70
0
40
% E
% Phe:
0
0
10
10
0
0
90
20
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
90
10
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
70
0
0
0
0
0
0
0
0
30
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
10
0
0
0
40
0
% I
% Lys:
60
10
10
0
0
0
10
0
0
0
0
0
0
0
40
% K
% Leu:
20
0
0
0
0
0
0
0
0
0
0
0
10
20
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
30
0
90
90
0
0
0
60
0
0
0
0
0
% P
% Gln:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
30
10
20
0
0
0
% S
% Thr:
0
0
10
0
0
0
0
0
10
0
0
10
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
80
0
0
10
10
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _