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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPMT
All Species:
26.98
Human Site:
Y240
Identified Species:
65.96
UniProt:
P51580
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51580
NP_000358.1
245
28180
Y240
D
C
L
F
E
K
L
Y
L
L
T
E
K
_
_
Chimpanzee
Pan troglodytes
Q3BCR8
245
28156
Y240
D
C
L
F
E
K
L
Y
L
L
T
E
K
_
_
Rhesus Macaque
Macaca mulatta
XP_001097433
245
28281
Y240
D
Y
L
F
E
K
L
Y
L
L
T
E
K
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O55060
240
27567
Y235
D
Y
L
F
E
K
L
Y
L
L
T
E
K
_
_
Rat
Rattus norvegicus
Q9Z0T0
240
27673
Y235
D
Y
F
F
E
K
L
Y
L
L
T
E
K
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508456
346
39120
Y341
D
Y
L
I
E
T
L
Y
L
F
T
V
K
_
_
Chicken
Gallus gallus
XP_418921
239
26809
Y233
D
Y
F
L
E
V
M
Y
L
V
K
F
V
A
_
Frog
Xenopus laevis
NP_001087908
243
27600
Y235
D
Y
Y
N
D
N
L
Y
L
V
T
L
K
S
S
Zebra Danio
Brachydanio rerio
Q504A5
232
26315
Y225
D
S
L
T
E
K
L
Y
L
L
T
T
K
T
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787330
226
26153
R221
T
W
M
R
Q
K
I
R
F
M
V
L
K
_
_
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
93
N.A.
N.A.
77.1
77.1
N.A.
47.9
55
46.1
49.3
N.A.
N.A.
N.A.
N.A.
35.9
Protein Similarity:
100
99.5
95.9
N.A.
N.A.
87.7
86.5
N.A.
58.6
69.8
66.9
65.3
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
92.3
N.A.
N.A.
92.3
84.6
N.A.
61.5
28.5
40
66.6
N.A.
N.A.
N.A.
N.A.
15.3
P-Site Similarity:
100
100
92.3
N.A.
N.A.
92.3
84.6
N.A.
61.5
42.8
53.3
66.6
N.A.
N.A.
N.A.
N.A.
46.1
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
90
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
80
0
0
0
0
0
0
50
0
0
0
% E
% Phe:
0
0
20
50
0
0
0
0
10
10
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
70
0
0
0
0
10
0
90
0
0
% K
% Leu:
0
0
60
10
0
0
80
0
90
60
0
20
0
0
0
% L
% Met:
0
0
10
0
0
0
10
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
10
% S
% Thr:
10
0
0
10
0
10
0
0
0
0
80
10
0
10
0
% T
% Val:
0
0
0
0
0
10
0
0
0
20
10
10
10
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
60
10
0
0
0
0
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
70
80
% _