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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH5A1
All Species:
9.39
Human Site:
T181
Identified Species:
18.79
UniProt:
P51649
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51649
NP_001071.1
535
57215
T181
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
Chimpanzee
Pan troglodytes
Q6A2H0
535
57110
T181
V
Y
G
D
I
I
Y
T
P
A
K
D
R
R
A
Rhesus Macaque
Macaca mulatta
XP_001101142
535
56988
T181
V
Y
G
D
I
I
Y
T
P
A
K
D
K
R
A
Dog
Lupus familis
XP_545368
482
51416
T171
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BWF0
523
55950
K174
I
Y
T
S
A
K
D
K
R
G
L
V
L
K
Q
Rat
Rattus norvegicus
P51650
523
56113
K174
I
Y
T
S
A
K
D
K
R
G
L
V
L
K
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418909
548
57904
A194
V
Y
G
D
V
I
P
A
S
A
K
D
R
R
I
Frog
Xenopus laevis
Q6GNL7
902
99964
P546
K
I
Q
G
R
T
I
P
I
N
Q
A
R
P
N
Zebra Danio
Brachydanio rerio
XP_002664997
514
55133
G176
L
I
L
K
Q
P
V
G
V
A
S
I
I
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789239
489
52301
A173
I
T
R
K
A
A
A
A
I
A
A
G
C
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SAK4
528
56541
P175
V
Y
G
D
I
I
P
P
N
L
S
D
R
R
L
Baker's Yeast
Sacchar. cerevisiae
P38067
497
54171
R172
F
P
S
A
M
I
T
R
K
A
A
A
A
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
96.4
76.4
N.A.
83.9
84.6
N.A.
N.A.
72.6
24.1
68.2
N.A.
N.A.
N.A.
N.A.
55.1
Protein Similarity:
100
99.6
97.5
81.8
N.A.
88.4
89.3
N.A.
N.A.
81.9
36.8
80.7
N.A.
N.A.
N.A.
N.A.
70.4
P-Site Identity:
100
93.3
86.6
6.6
N.A.
6.6
6.6
N.A.
N.A.
66.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
6.6
N.A.
20
20
N.A.
N.A.
73.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.1
44.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
71.2
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
17
34
9
9
17
0
59
17
17
9
9
34
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% C
% Asp:
0
0
0
42
0
0
17
0
0
0
0
42
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
42
9
0
9
0
9
0
17
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
25
17
0
0
34
50
9
0
17
0
0
9
9
0
9
% I
% Lys:
9
0
0
17
0
17
0
17
9
0
34
9
9
17
0
% K
% Leu:
9
0
17
0
0
0
0
0
0
9
17
0
17
9
9
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
9
0
0
0
0
9
% N
% Pro:
0
9
0
0
0
9
17
17
25
0
0
0
9
9
9
% P
% Gln:
0
0
9
0
9
0
0
0
0
0
9
0
0
0
17
% Q
% Arg:
0
0
9
0
9
0
0
9
17
0
0
0
42
42
0
% R
% Ser:
0
0
9
17
0
0
0
0
9
0
17
0
0
0
0
% S
% Thr:
0
9
17
0
0
9
9
34
0
0
0
0
0
17
0
% T
% Val:
42
0
0
0
9
0
9
0
17
9
9
17
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
59
0
0
0
0
17
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _