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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B4
All Species:
35.15
Human Site:
S185
Identified Species:
59.49
UniProt:
P51659
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51659
NP_000405.1
736
79686
S185
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
Chimpanzee
Pan troglodytes
XP_517892
712
77651
S161
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
Rhesus Macaque
Macaca mulatta
XP_001087837
734
79298
S185
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
Dog
Lupus familis
XP_531860
737
79671
S186
L
A
I
E
G
K
T
S
N
I
H
C
N
T
I
Cat
Felis silvestris
Mouse
Mus musculus
P51660
735
79463
N185
L
A
I
E
G
R
K
N
N
I
H
C
N
T
I
Rat
Rattus norvegicus
P97852
735
79409
N185
L
V
I
E
G
R
K
N
N
I
H
C
N
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512505
752
82654
Y189
L
A
I
E
G
R
K
Y
N
I
H
C
N
S
I
Chicken
Gallus gallus
NP_990274
735
80130
Y185
I
A
I
E
G
R
K
Y
N
I
H
C
N
T
I
Frog
Xenopus laevis
NP_001086063
741
80382
Y186
L
A
I
E
G
T
K
Y
N
I
Q
S
N
C
I
Zebra Danio
Brachydanio rerio
NP_956430
725
78606
Y185
L
A
I
E
G
Q
K
Y
N
I
H
C
N
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573109
598
64055
K91
K
V
I
E
T
A
I
K
A
F
G
R
V
D
I
Honey Bee
Apis mellifera
XP_393475
704
78091
K186
L
A
I
E
G
K
Q
K
N
I
H
T
N
V
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q02207
900
98685
Y186
L
A
K
E
G
A
K
Y
N
I
N
V
N
S
I
Red Bread Mold
Neurospora crassa
Q01373
894
96308
Y185
L
A
K
E
G
L
K
Y
N
I
I
S
N
V
I
Conservation
Percent
Protein Identity:
100
94.8
97.2
87.2
N.A.
86.2
87.3
N.A.
68
71.3
70.7
68
N.A.
45.3
50
N.A.
N.A.
Protein Similarity:
100
95.7
98.5
92.6
N.A.
93.3
93.7
N.A.
81.3
83.8
83.8
81.5
N.A.
59
67.1
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
93.3
86.6
N.A.
86.6
86.6
66.6
86.6
N.A.
20
66.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
93.3
N.A.
93.3
93.3
66.6
93.3
N.A.
20
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.4
29.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46
45.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
60
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
86
0
0
0
15
0
0
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
65
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
93
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
0
% H
% Ile:
8
0
86
0
0
0
8
0
0
93
8
0
0
0
100
% I
% Lys:
8
0
15
0
0
15
79
15
0
0
0
0
0
0
0
% K
% Leu:
86
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
15
93
0
8
0
93
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
8
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
50
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
29
0
0
0
15
0
15
0
% S
% Thr:
0
0
0
0
8
8
8
0
0
0
0
8
0
58
0
% T
% Val:
0
15
0
0
0
0
0
0
0
0
0
8
8
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _