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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B4
All Species:
20.3
Human Site:
S624
Identified Species:
34.36
UniProt:
P51659
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51659
NP_000405.1
736
79686
S624
S
E
G
G
K
L
Q
S
T
F
V
F
E
E
I
Chimpanzee
Pan troglodytes
XP_517892
712
77651
S600
S
E
G
E
K
L
Q
S
T
L
V
F
E
E
I
Rhesus Macaque
Macaca mulatta
XP_001087837
734
79298
S622
S
E
G
G
K
L
Q
S
T
L
V
F
E
E
I
Dog
Lupus familis
XP_531860
737
79671
S625
S
E
G
G
E
L
Q
S
T
L
V
F
E
E
I
Cat
Felis silvestris
Mouse
Mus musculus
P51660
735
79463
S623
S
E
G
G
E
L
Q
S
A
L
V
F
G
E
I
Rat
Rattus norvegicus
P97852
735
79409
S623
S
E
G
G
A
L
Q
S
A
L
V
F
G
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512505
752
82654
T628
T
I
K
V
G
E
S
T
R
I
P
S
L
C
V
Chicken
Gallus gallus
NP_990274
735
80130
D624
P
T
A
G
L
Q
S
D
L
V
F
E
E
I
G
Frog
Xenopus laevis
NP_001086063
741
80382
Q627
A
V
Q
D
G
G
L
Q
S
D
L
V
F
E
E
Zebra Danio
Brachydanio rerio
NP_956430
725
78606
L617
Q
T
E
L
Q
S
D
L
V
F
A
E
I
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573109
598
64055
A507
L
H
I
D
P
Q
M
A
L
L
A
G
F
K
T
Honey Bee
Apis mellifera
XP_393475
704
78091
K613
K
T
N
S
D
E
V
K
K
I
N
G
V
F
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q02207
900
98685
H754
S
F
F
I
R
G
A
H
V
P
P
E
K
E
V
Red Bread Mold
Neurospora crassa
Q01373
894
96308
G709
K
Y
P
I
P
T
S
G
R
L
V
S
K
G
K
Conservation
Percent
Protein Identity:
100
94.8
97.2
87.2
N.A.
86.2
87.3
N.A.
68
71.3
70.7
68
N.A.
45.3
50
N.A.
N.A.
Protein Similarity:
100
95.7
98.5
92.6
N.A.
93.3
93.7
N.A.
81.3
83.8
83.8
81.5
N.A.
59
67.1
N.A.
N.A.
P-Site Identity:
100
86.6
93.3
86.6
N.A.
73.3
73.3
N.A.
0
13.3
6.6
13.3
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
86.6
93.3
93.3
N.A.
80
73.3
N.A.
20
13.3
26.6
20
N.A.
13.3
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.4
29.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46
45.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
8
0
8
8
15
0
15
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
15
8
0
8
8
0
8
0
0
0
0
0
% D
% Glu:
0
43
8
8
15
15
0
0
0
0
0
22
36
65
8
% E
% Phe:
0
8
8
0
0
0
0
0
0
15
8
43
15
8
0
% F
% Gly:
0
0
43
43
15
15
0
8
0
0
0
15
15
8
8
% G
% His:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
15
0
0
0
0
0
15
0
0
8
8
43
% I
% Lys:
15
0
8
0
22
0
0
8
8
0
0
0
15
8
8
% K
% Leu:
8
0
0
8
8
43
8
8
15
50
8
0
8
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
8
0
8
0
15
0
0
0
0
8
15
0
0
0
0
% P
% Gln:
8
0
8
0
8
15
43
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
15
0
0
0
0
0
8
% R
% Ser:
50
0
0
8
0
8
22
43
8
0
0
15
0
0
0
% S
% Thr:
8
22
0
0
0
8
0
8
29
0
0
0
0
0
8
% T
% Val:
0
8
0
8
0
0
8
0
15
8
50
8
8
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _