Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSD17B4 All Species: 52.42
Human Site: T149 Identified Species: 88.72
UniProt: P51659 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51659 NP_000405.1 736 79686 T149 K Y G R I I M T S S A S G I Y
Chimpanzee Pan troglodytes XP_517892 712 77651 T125 K Y G R I I M T S S A S G I Y
Rhesus Macaque Macaca mulatta XP_001087837 734 79298 T149 K Y G R I I M T S S A S G I Y
Dog Lupus familis XP_531860 737 79671 T150 K F G R I V M T S S A S G I Y
Cat Felis silvestris
Mouse Mus musculus P51660 735 79463 T149 N Y G R I L M T S S A S G I Y
Rat Rattus norvegicus P97852 735 79409 T149 N Y G R I I M T A S A S G I Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512505 752 82654 T153 N F G R I I M T S S A A G I Y
Chicken Gallus gallus NP_990274 735 80130 T149 K F G R I I M T S S A A G I Y
Frog Xenopus laevis NP_001086063 741 80382 T150 K F G R I I M T S S A A G I Y
Zebra Danio Brachydanio rerio NP_956430 725 78606 T149 K F G R I I M T S S A A G I Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573109 598 64055 Q55 H S G D G A S Q R A A D I V V
Honey Bee Apis mellifera XP_393475 704 78091 T150 K Y G R I I M T A S N S G L Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q02207 900 98685 T150 K F G R I I N T A S P A G L F
Red Bread Mold Neurospora crassa Q01373 894 96308 T149 K F G R V I N T A S A A G L F
Conservation
Percent
Protein Identity: 100 94.8 97.2 87.2 N.A. 86.2 87.3 N.A. 68 71.3 70.7 68 N.A. 45.3 50 N.A. N.A.
Protein Similarity: 100 95.7 98.5 92.6 N.A. 93.3 93.7 N.A. 81.3 83.8 83.8 81.5 N.A. 59 67.1 N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. 80 86.6 86.6 86.6 N.A. 13.3 80 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 100 100 100 N.A. 26.6 93.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.4 29.7
Protein Similarity: N.A. N.A. N.A. N.A. 46 45.8
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 53.3
P-Site Similarity: N.A. N.A. N.A. N.A. 86.6 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 0 29 8 86 43 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 50 0 0 0 0 0 0 0 0 0 0 0 0 15 % F
% Gly: 0 0 100 0 8 0 0 0 0 0 0 0 93 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 86 79 0 0 0 0 0 0 8 72 0 % I
% Lys: 72 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 8 0 0 0 0 0 0 0 22 0 % L
% Met: 0 0 0 0 0 0 79 0 0 0 0 0 0 0 0 % M
% Asn: 22 0 0 0 0 0 15 0 0 0 8 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 93 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 0 8 0 0 0 0 8 0 65 93 0 50 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 93 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 8 8 0 0 0 0 0 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 43 0 0 0 0 0 0 0 0 0 0 0 0 79 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _