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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B4
All Species:
16.06
Human Site:
T319
Identified Species:
27.18
UniProt:
P51659
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51659
NP_000405.1
736
79686
T319
H
T
S
R
A
T
S
T
A
T
S
G
F
A
G
Chimpanzee
Pan troglodytes
XP_517892
712
77651
T295
H
T
S
R
A
T
S
T
A
T
S
G
F
A
G
Rhesus Macaque
Macaca mulatta
XP_001087837
734
79298
T318
H
T
S
H
A
T
S
T
A
T
S
G
F
A
G
Dog
Lupus familis
XP_531860
737
79671
T320
H
T
S
H
A
A
S
T
A
T
S
E
F
A
G
Cat
Felis silvestris
Mouse
Mus musculus
P51660
735
79463
A318
R
T
S
H
A
A
P
A
A
T
S
G
F
V
G
Rat
Rattus norvegicus
P97852
735
79409
A318
H
T
G
Q
V
A
S
A
D
A
S
G
F
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512505
752
82654
V323
P
T
S
Q
A
A
S
V
A
K
S
Q
L
D
R
Chicken
Gallus gallus
NP_990274
735
80130
V319
S
T
N
S
R
S
V
V
S
S
A
V
D
T
T
Frog
Xenopus laevis
NP_001086063
741
80382
S322
S
H
G
T
S
L
S
S
S
S
I
D
P
A
K
Zebra Danio
Brachydanio rerio
NP_956430
725
78606
P319
P
T
A
V
A
T
N
P
A
Q
A
I
G
H
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573109
598
64055
N214
I
L
P
D
I
L
F
N
E
L
K
P
K
L
I
Honey Bee
Apis mellifera
XP_393475
704
78091
S314
E
N
S
Q
P
S
E
S
Q
N
S
G
V
L
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q02207
900
98685
V325
K
S
L
C
N
K
V
V
V
V
T
G
A
G
G
Red Bread Mold
Neurospora crassa
Q01373
894
96308
F334
G
R
A
Y
C
L
A
F
A
R
A
G
A
S
V
Conservation
Percent
Protein Identity:
100
94.8
97.2
87.2
N.A.
86.2
87.3
N.A.
68
71.3
70.7
68
N.A.
45.3
50
N.A.
N.A.
Protein Similarity:
100
95.7
98.5
92.6
N.A.
93.3
93.7
N.A.
81.3
83.8
83.8
81.5
N.A.
59
67.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
60
53.3
N.A.
40
6.6
13.3
26.6
N.A.
0
20
N.A.
N.A.
P-Site Similarity:
100
100
93.3
80
N.A.
60
60
N.A.
46.6
40
40
46.6
N.A.
0
40
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.4
29.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46
45.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
50
29
8
15
58
8
22
0
15
43
0
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
0
8
8
8
0
% D
% Glu:
8
0
0
0
0
0
8
0
8
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
8
0
0
0
0
43
0
0
% F
% Gly:
8
0
15
0
0
0
0
0
0
0
0
58
8
8
50
% G
% His:
36
8
0
22
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
0
8
0
0
0
0
0
8
8
0
0
8
% I
% Lys:
8
0
0
0
0
8
0
0
0
8
8
0
8
0
8
% K
% Leu:
0
8
8
0
0
22
0
0
0
8
0
0
8
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
8
8
0
8
0
0
0
0
0
% N
% Pro:
15
0
8
0
8
0
8
8
0
0
0
8
8
0
0
% P
% Gln:
0
0
0
22
0
0
0
0
8
8
0
8
0
0
0
% Q
% Arg:
8
8
0
15
8
0
0
0
0
8
0
0
0
0
15
% R
% Ser:
15
8
50
8
8
15
50
15
15
15
58
0
0
8
0
% S
% Thr:
0
65
0
8
0
29
0
29
0
36
8
0
0
8
8
% T
% Val:
0
0
0
8
8
0
15
22
8
8
0
8
8
8
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _