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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B4
All Species:
30.91
Human Site:
Y414
Identified Species:
52.31
UniProt:
P51659
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51659
NP_000405.1
736
79686
Y414
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
A
G
Chimpanzee
Pan troglodytes
XP_517892
712
77651
Y390
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
A
G
Rhesus Macaque
Macaca mulatta
XP_001087837
734
79298
K413
E
P
S
M
K
A
E
K
P
L
K
R
V
G
K
Dog
Lupus familis
XP_531860
737
79671
Y415
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
A
G
Cat
Felis silvestris
Mouse
Mus musculus
P51660
735
79463
Y413
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
S
G
Rat
Rattus norvegicus
P97852
735
79409
Y413
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512505
752
82654
Y418
G
E
Q
Y
L
E
V
Y
K
L
F
P
S
S
G
Chicken
Gallus gallus
NP_990274
735
80130
Y414
G
E
Q
Y
L
E
L
Y
K
P
L
P
T
S
G
Frog
Xenopus laevis
NP_001086063
741
80382
Y417
G
E
Q
Y
L
E
V
Y
K
P
L
P
T
S
G
Zebra Danio
Brachydanio rerio
NP_956430
725
78606
G414
Y
K
P
L
P
T
S
G
T
L
T
S
R
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573109
598
64055
G309
V
L
E
K
L
K
E
G
G
G
D
A
I
E
D
Honey Bee
Apis mellifera
XP_393475
704
78091
T409
K
Q
L
P
T
E
A
T
V
E
T
R
Y
K
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q02207
900
98685
E420
F
L
K
M
K
D
E
E
W
F
A
V
L
K
V
Red Bread Mold
Neurospora crassa
Q01373
894
96308
W429
Y
K
V
T
K
A
A
W
P
Y
F
L
K
Q
K
Conservation
Percent
Protein Identity:
100
94.8
97.2
87.2
N.A.
86.2
87.3
N.A.
68
71.3
70.7
68
N.A.
45.3
50
N.A.
N.A.
Protein Similarity:
100
95.7
98.5
92.6
N.A.
93.3
93.7
N.A.
81.3
83.8
83.8
81.5
N.A.
59
67.1
N.A.
N.A.
P-Site Identity:
100
100
0
100
N.A.
93.3
93.3
N.A.
66.6
86.6
80
13.3
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
100
0
100
N.A.
100
100
N.A.
80
93.3
93.3
20
N.A.
20
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.4
29.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46
45.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
15
15
0
0
0
8
8
0
29
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% D
% Glu:
8
58
8
0
0
65
22
8
0
8
0
0
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
15
0
0
0
0
% F
% Gly:
58
0
0
0
0
0
0
15
8
8
0
0
0
8
58
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% I
% Lys:
8
15
8
8
22
8
0
8
58
0
8
0
8
15
15
% K
% Leu:
0
15
8
8
65
0
43
0
0
22
50
8
8
0
0
% L
% Met:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
8
8
8
0
0
0
15
50
0
58
0
0
0
% P
% Gln:
0
8
58
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
15
43
0
0
% R
% Ser:
0
0
8
0
0
0
8
0
0
0
0
8
8
36
0
% S
% Thr:
0
0
0
8
8
8
0
8
8
0
15
0
15
0
8
% T
% Val:
8
0
8
0
0
0
15
0
8
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% W
% Tyr:
15
0
0
58
0
0
0
58
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _