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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B4
All Species:
40.61
Human Site:
Y448
Identified Species:
68.72
UniProt:
P51659
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51659
NP_000405.1
736
79686
Y448
I
I
M
D
V
Y
S
Y
S
E
K
E
L
I
C
Chimpanzee
Pan troglodytes
XP_517892
712
77651
Y424
I
I
M
D
V
Y
S
Y
S
E
K
E
L
I
C
Rhesus Macaque
Macaca mulatta
XP_001087837
734
79298
Y446
I
I
M
D
V
Y
S
Y
S
E
K
E
L
I
C
Dog
Lupus familis
XP_531860
737
79671
Y449
I
L
V
D
V
Y
S
Y
F
E
E
E
L
I
C
Cat
Felis silvestris
Mouse
Mus musculus
P51660
735
79463
Y447
I
V
M
D
V
Y
S
Y
S
G
K
E
L
I
C
Rat
Rattus norvegicus
P97852
735
79409
Y447
I
V
M
D
V
Y
S
Y
S
G
K
E
L
I
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512505
752
82654
Y452
I
L
F
D
V
T
T
Y
H
E
K
E
L
I
C
Chicken
Gallus gallus
NP_990274
735
80130
Y448
L
L
I
D
V
N
T
Y
C
G
K
D
L
V
C
Frog
Xenopus laevis
NP_001086063
741
80382
Y451
I
L
L
D
V
H
T
Y
H
G
A
D
L
I
C
Zebra Danio
Brachydanio rerio
NP_956430
725
78606
Y441
I
L
L
D
V
H
T
Y
S
E
Q
E
L
L
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573109
598
64055
S335
Y
A
L
G
I
G
A
S
V
K
N
A
K
D
M
Honey Bee
Apis mellifera
XP_393475
704
78091
T437
I
Q
H
D
T
F
D
T
S
N
E
D
K
L
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q02207
900
98685
P499
I
I
V
N
V
I
A
P
H
A
E
T
A
M
T
Red Bread Mold
Neurospora crassa
Q01373
894
96308
L519
V
A
P
L
V
L
A
L
C
S
D
K
V
P
K
Conservation
Percent
Protein Identity:
100
94.8
97.2
87.2
N.A.
86.2
87.3
N.A.
68
71.3
70.7
68
N.A.
45.3
50
N.A.
N.A.
Protein Similarity:
100
95.7
98.5
92.6
N.A.
93.3
93.7
N.A.
81.3
83.8
83.8
81.5
N.A.
59
67.1
N.A.
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
86.6
86.6
N.A.
66.6
40
46.6
60
N.A.
0
20
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
80
80
80
100
N.A.
26.6
46.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.4
29.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46
45.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
0
0
0
22
0
0
8
8
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
72
% C
% Asp:
0
0
0
79
0
0
8
0
0
0
8
22
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
43
22
58
0
0
0
% E
% Phe:
0
0
8
0
0
8
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
29
0
0
0
0
0
% G
% His:
0
0
8
0
0
15
0
0
22
0
0
0
0
0
0
% H
% Ile:
79
29
8
0
8
8
0
0
0
0
0
0
0
58
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
50
8
15
0
8
% K
% Leu:
8
36
22
8
0
8
0
8
0
0
0
0
72
15
0
% L
% Met:
0
0
36
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
8
0
8
0
0
0
8
8
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
43
8
50
8
0
0
0
0
8
% S
% Thr:
0
0
0
0
8
8
29
8
0
0
0
8
0
0
8
% T
% Val:
8
15
15
0
86
0
0
0
8
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
43
0
72
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _